Transcriptional regulatory mechanisms have a dual role in specifying intestinal epithelial identity and enabling microbial responsiveness. In this Review, Rawls and colleagues describe what is currently known about the epigenetic patterning and transcription factors responsible for this duality.
Nature Reviews Gastroenterology & Hepatology – Hepatocellular carcinoma (HCC) accounts for approximately 80% of all cases of primary liver cancer, the third leading cause of…
Nature Reviews Gastroenterology & Hepatology – Steatotic liver disease (SLD) encompasses a spectrum of hepatic lipid-accumulation disorders, including metabolic and alcohol-related liver…
This position statement explores the intricate relationship between alcohol intake and metabolic dysfunction in the context of the 2023 nomenclature for steatotic liver disease (SLD).…
Nature Reviews Gastroenterology & Hepatology – Hepatic vagus nerve relays signals to the brain that can alter food intake
Nature Reviews Gastroenterology & Hepatology – Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressive advances over the…
Nature – An investigation into the relationship between network structure and gut microbiome composition among people living in 18 isolated Honduras villages reveals that strain-sharing…
Nature Reviews Gastroenterology & Hepatology – Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by…
Nature Reviews Gastroenterology & Hepatology – The ins and outs of tumour resistance
Nature Reviews Gastroenterology & Hepatology – Non-canonical metastatic colorectal cancer
Nature Reviews Gastroenterology & Hepatology – Although fermented foods have been consumed for thousands of years, a clear definition has been lacking. This Consensus Statement…
