Besides respiratory symptoms, diarrhea is one of the other commonly observed disease manifestations in patients with COVID-19. Zang et al. used organoid cultures of epithelial lining cells from human small and large intestine as an in vitro model system to study SARS-CoV-2 entry and replication in enterocytes. Mature enterocytes expressing the highest levels of the angiotensin-converting enzyme 2…
On 28 April 2006, Science published the Report “Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1a” by C.…
A novelist’s venture into nonfiction is filled with deep insights about life on Earth but may leave some wanting more
Jupiter’s moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io’s inventory of volatile chemical elements, including sulfur and chlorine, reflects…
Therapeutic oligonucleotides are a powerful drug modality with the potential to treat many diseases. The rapidly growing number of therapies that have been approved and…
A spring-loaded lid that flings insects to their doom has emerged at least twice
Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles, which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the reduction…
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition.
A key mentor ’helped me see that engaging with the people around me would improve my state of mind,“ this researcher writes
Bold action is needed to address unmanageable time scales, limited access to information, and a need to build capacity
On this week’s show: Researchers are testing HIV drugs and monoclonal antibodies against long-lasting COVID-19, and what it takes to turn a symbiotic friend into…
