Storing excess lipid in subcutaneous fat is more metabolically favorable than in visceral fat. Hsiao et al. show that mTORC2 is required during subcutaneous fat development to establish lipid handling capacity. Without mTORC2, developing subcutaneous fat is reduced and lipid is redistributed to other depots, causing gender-specific consequences.
Guo et al. find that when mice repeatedly explore a novel environment, a distinct subset of neurons in the CA1 region of the hippocampus, which initially…
In this study, Valentino et al. explored the diversity of the genus Ruminococcus, highlighting associations between species/subspecies prevalence and geographic origin, lifestyle, age, and disease. Furthermore,…
(Cell Reports 34, 108814; March 9, 2021)
Hamamoto et al. report that disrupting the VPS37A ubiquitin E2 variant-like domain impairs autophagosome closure, resulting in milder autophagy-defective phenotypes in mice compared to those lacking…
Alcobia et al. explore the thymic potential of non-canonical pharyngeal pouches (PPs) using quail-chick chimeras. They show that 2PP shares thymic potential with canonical 3/4PP and…
Sun et al. demonstrate that APOE3 Christchurch microglia protect neurons from Aβ-induced Tau pathology by regulating lipid peroxidation and phagocytosis. Targeting APOE and lipid metabolism in…
The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients…
Lu et al. explore the mechanism of sorafenib resistance in hepatocellular carcinoma, showing that carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated pHi dysregulation under…
Basal ganglia dysfunction potentially causes behavioral alterations in ASD. Carbonell-Roig et al. show that the eIF4E Tg mouse model of ASD exhibits behavioral inflexibility and impaired…
Wang et al. report that nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma. Acetyl-CoA promotes PD-L1 transcription via P300-mediated histone acetylation to suppress…
