Objectives: The majority of patients with mild-to-moderate COVID-19 can be managed using virtual care. Dyspnea is challenging to assess remotely, and the accuracy of subjective dyspnea measures in capturing hypoxemia have not been formally evaluated for COVID-19. We explored the accuracy of subjective dyspnea in diagnosing hypoxemia in COVID-19 patients. Methods: This is a retrospective cohort…
American Journal of Cardiovascular Drugs – The renin–angiotensin–aldosterone system plays an important role in the pathophysiology of hypertension and is closely related with cardio-…
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB),…
European Journal of Clinical Pharmacology – Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9. In this study, we determined the effects…
Acta Pharmacologica Sinica – Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Two active metabolites of the angiotensin type 1 (AT1) receptor blocker losartan have been described previously, EXP3174 and EXP3179. Whereas EXP3174 is the main antihypertensive…
Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin…
Alcohol is one of the most commonly used drugs in America, and it is also one of the deadliest, with more and more people losing…
Alcohol is one of the most commonly used drugs in America, and it is also one of the deadliest, with more and more people losing…
Perioperative corticosteroids have shown potential as non-opioid analgesic adjuncts for various orthopedic pathologies, but there is a lack of research on their use in the…
We conducted a target trial emulation to assess vaccine safety and risk of mortality in the 60 days after the first dose of coronavirus disease…
