Targeted drugs ramp up cancer mutability

Mutagenesis can drive carcinogenesis and continue during cancer progression, generating genetic intratumor heterogeneity that enables cancer adaptation through Darwinian evolution ([ 1 ][1]). Analyses, such as mutational signature characterization, have revealed specific mutational processes and their temporal activity during carcinogenesis and tumor progression ([ 2 ][2]). Nevertheless, many of…

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