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Mashup Score: 13XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells - 2 year(s) ago
In XIAP deficiency, ileitis is driven by TNFR1- and TNFR2-dependent targeting of TLR5-expressing Paneth and dendritic cells.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Hematopoietic Cell Transplantation Rescues Inflammatory Bowel Disease and Dysbiosis of Gut Microbiota in XIAP Deficiency - 3 year(s) ago
X-linked inhibitor of apoptosis protein (XIAP) deficiency is an infrequent inborn error of immunity that is often associated with refractory inflammatory bowel disease (IBD). The natural course of XIAP deficiency is typically associated with poor prognosis, and hematopoietic cell transplantation (HCT) is the only curative treatment.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Current Issue (Free)! #Hematopoietic #Cell #Transplantation Rescues #Inflammatory #Bowel #Disease and #Dysbiosis of #Gut #Microbiota in #XIAP #Deficiency https://t.co/mh7jKKoqKq https://t.co/V6wJsowcOe
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Mashup Score: 0Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency - 3 year(s) ago
X-linked inhibitor of apoptosis protein (XIAP) deficiency is an infrequent inborn error of immunity that is often associated with refractory inflammatory bowel disease (IBD). The natural course of XIAP deficiency is typically associated with poor prognosis, and hematopoietic cell transplantation (HCT) is the only curative treatment.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Press! #Hematopoietic #cell #transplantation rescues #inflammatory #bowel #disease and #dysbiosis of #gut #microbiota in #XIAP #deficiency https://t.co/mh7jKKoqKq
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Mashup Score: 0X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc) - 3 year(s) ago
Objective X-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important functions in apoptosis, cellular differentiation and cytoskeletal organisation and is emerging as potential target for the treatment of various cancers. The aim of the current study was to investigate the role of XIAP in the pathogenesis of systemic sclerosis (SSc). Methods The expression of XIAP…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
❓What is the role for #XIAP in #SSc? ▶️XIAP increased in #SSc fibroblast ▶️TGFb-dependent ▶️XIAP inhibition atenuate #SSc and #WNT pathway 🧐XIAP inhibition to target two core pathways in #SSc? 🔗https://t.co/9xlUbGF59Y https://t.co/5TbeUpNMtX
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Mashup Score: 3Recurrent lymphadenitis in a female XIAP/BIRC4 mutation carrier with normal lyonization - 3 year(s) ago
Deficiency of X-linked inhibitor of apoptosis (XIAP) caused by mutations in XIAP (also known as BIRC4) is a cause of X-linked lymphoproliferative disease,1 characterized by Epstein Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis and hypogammaglobulinemia. Patients with XIAP deficiency also suffer from increased risk of inflammatory conditions such as inflammatory bowel disease…
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Current Issue! Recurrent #lymphadenitis in a female #XIAP/ #BIRC4 #mutation #carrier with normal #lyonization https://t.co/d388zPgYBa https://t.co/RWLP9oLUWM
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Mashup Score: 0Recurrent lymphadenitis in a female XIAP/BIRC4 mutation carrier with normal lyonization - 3 year(s) ago
Article InfoPublication HistoryAccepted: October 1, 2020Received in revised form: September 16, 2020Received: February 18, 2020Publication stageIn Press Journal Pre-ProofFootnotesCOI Statement:JDS, HSK, JS, JN, GS, SR, and JDM have no conflicts of interest to disclose. MDK has served as a consultant to Gilead…
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Press! Recurrent #lymphadenitis in a female #XIAP / #BIRC4 #mutation #carrier with normal #lyonization https://t.co/4zijlcf39r https://t.co/S5gs5cHe6D
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Two new studies in mice show how #XIAP protein deficiency leads to #IBD inflammation, with antimicrobial #peptides as possible therapy. Read more ⬇ https://t.co/LXTXIzggxR https://t.co/328pWMR7nr https://t.co/xT4UaiLsPr