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    Studies across a range of solid tumor types, including breast, ovarian, and pancreatic cancers, have demonstrated clinical benefit with poly (ADP-ribose) polymerase (PARP) inhibition, particularly in patients harboring alterations in DNA damage response (DDR) genes such as BRCA1/2. A growing body of evidence also suggests that PARP inhibition may be effective in a broader range of DDR alterations.

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    • What do you consider the most likely explanation for the modest activity of polymerase inhibition in metastatic #urothelial cancer and why? #Bladder #oncology @ASCO #ASCOReadingRoom Read more: https://t.co/VMHmhtHAsU https://t.co/D6TjmlhNOB

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    Wolters Kluwer Health - 11 month(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

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    • #Urothelial cancer treatments are subject to factors such as tumor type and stage. Clarifying the molecular landscape can help distinguish specific subtypes and help develop targeted therapy. @BladderCancerUS https://t.co/HsNjLJQSiS https://t.co/3cyfsatAmp

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    Wolters Kluwer Health - 12 month(s) ago

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    • The @US_FDA recently granted accelerated approval to enfortumab vedotin-ejfv with pembrolizumab for patients with locally advanced or metastatic #urothelial carcinoma who are ineligible for cisplatin-containing chemotherapy. https://t.co/TVoscIlLy7 https://t.co/kgL13b6YbQ

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    Wolters Kluwer Health - 12 month(s) ago

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    • #Urothelial cancer treatments are subject to factors such as tumor type and stage. Clarifying the molecular landscape can help distinguish specific subtypes and help develop targeted therapy. @BladderCancerUS https://t.co/HsNjLJQSiS https://t.co/wRxY7qZTVx

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    AUA 2023, upper tract urothelial cancers (UTUC), urine cytology, Oncuria, angiogenin (ANG), apolipoprotein E (APOE), alpha-1 antitrypsin (A1AT), carbonic anhydrase 9 (CA9), interleukin-8 (IL-8), matrix metallopeptidase 9 (MMP9), matrix metallopeptidase 10 (MMP10), plasminogen activator inhibitor 1 (PAI1), syndecan 1 (SDC1), and vascular endothelial growth factor (VEGF).

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    • Diagnostic accuracy of Oncuria-Detect in the detection of upper tract #Urothelial tumors. Presentation by Hideki Furuya, MD @CedarsSinai. #AUA23 written coverage by @RuchikaTalwarMD @VUMCurology > https://t.co/MTcEluyrj1 @AmerUrological https://t.co/MkZCvHxDGM