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Mashup Score: 42018 Leibovich prognostic model for renal cell carcinoma: Performance in a large population with special consideration of Black race - 6 month(s) ago
The authors examined and externally validated the 2018 Leibovich prognostic model for nonmetastatic renal cell carcinoma in a large population with greater Black patient representation. The results i…
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Mashup Score: 0Managing pancreatic neuroendocrine tumors - 6 month(s) ago
Pamela L. Kunz, MD, Yale University School of Medicine, New Haven, CT, talks on the challenging of managing endocrine tumors, including determination of treatment sequencing. Patients with low-grade or slow growing endocrine tumors tend to be treated with first-line somatostatin analogues, such as octreotide or lanreotide, with options expanding within the second-line treatment setting. Upcoming trials are utilizing comparator arms, including a Phase II trial (NCT05247905) comparing capecitabine plus temozolomide to lutetium Lu 177-dotatate in advanced pancreatic neuroendocrine tumors. Such trials enables comparison of active agents which has previously been lacking in the field. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Hot Topics in Renal Cell Carcinoma and Rare Tumors - 6 month(s) ago
In this podcast we’ll hear from experts in GU cancer on some of the most exciting clinical trial data in…
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Belzutifan real-world vs clinical trial data: comparing efficacy and safety in VHL-associated tumors - 6 month(s) ago
Anusha Chidharla, MBBS, University of Kansas Medical Center, Kansas City, MO, compares the real-world data of belzutifan in VHL-associated tumors versus clinical trial data. The objective response rate (ORR) for associated renal cell cancer was 23%, lower than the clinical trial’s 49%, likely due to shorter follow-up duration (8 months vs. 21 months) and less frequent scans. Safety findings were similar, with common side effects being anemia and fatigue (65-70%). Belzutifan dose was decreased in 30% of our patients (vs. 15% in the clinical trial) due to poorer performance status (ECOG 1-2 vs. ECOG 0). These results highlight the importance of longer follow-up and more frequent scans to capture treatment responses accurately in the real-world setting. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0VJOncology – The video journal of oncology - 6 month(s) ago
The Video Journal of Oncology (VJOncology) is an independent, global, open-access video journal, dedicated to providing trusted and up-to-date information in order to improve the awareness and understanding of oncology
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Exclusive highlights in genitourinary cancer at ASCO 2023 - 7 month(s) ago
Pedro Barata, MD, University Hospitals Seidman Cancer Center, Cleveland, OH, provides important updates in genitourinary cancer at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress, including findings from the PEACE-1 trial (NCT01957436), as well as updates in PARP inhibitors with radioligands in prostate cancer. Dr Barata additionally comments on trials assessing salvage chemotherapy in renal cell carcinoma (RCC) and targeting EGFR in bladder cancer. This interview took place at the ASCO 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0VJOncology – The video journal of oncology - 7 month(s) ago
The Video Journal of Oncology (VJOncology) is an independent, global, open-access video journal, dedicated to providing trusted and up-to-date information in order to improve the awareness and understanding of oncology
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0The role of SLAMF7-positive, CD8-positive T-cells in therapeutic resistance in kidney cancer - 7 month(s) ago
David A. Braun, MD, PhD, Yale School of Medicine, New Haven, CT, explains how a transitional study used advanced genomic techniques, such as single cell approaches, to uncover the causes of resistance to anti-PD1 therapy. Single cell RNA sequencing analysis from various clinical trial samples showed that slightly exhausted T-cells that expressed markers such as SLAMF7, were strongly linked with therapeutic resistance. This finding needs to be corroborated in other studies and requires functional testing, to uncover if this is a biomarker, predictive factor, or a component that can be modulated. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0MAIN-CAV: maintenance cabozantinib and avelumab in urothelial cancer - 7 month(s) ago
Shilpa Gupta, MD, Cleveland Clinic, Cleveland, OH, talks on the trial design of the Phase III MAIN-CAV trial (NCT05092958) of maintenance cabozantinib and avelumab in patients with metastatic urothelial cancer. Based on the JAVELIN Bladder 100 trial (NCT02603432), maintenance avelumab is considered the standard of care in this setting, but responses remain poor in patients with certain metastases. The MAIN-CAV will assess the addition of cabozantinib in patients pre-treated with platinum-based chemotherapy, and overall survival will be the primary objective. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0How can we best sequence novel treatments in urothelial cancer? - 7 month(s) ago
Daniel Petrylak, MD, Yale School of Medicine, New Haven, CT, comments on the changing field of urothelial cancer, including novel therapies such as enfortumab vedotin and erdafitinib, which have been assessed in the EV-103 trial (NCT03288545) and THOR (NCT03390504) trials, as well as sacituzumab govitecan. Treatment can depend on the FGFR status of patients, where erdafitinib has shown benefit in patients with FGFR alterations. Adverse events can additionally influence which drug a patient will receive. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
In a new study, @b_schmeusser and colleagues validate the 2018 Leibovich prognostic model for #RenalCellCarcinoma in a cohort w/ 657 (29%) Black patients, a previously underexamined population. https://t.co/GK6dYQvS9r @OncoAlert @EdouardNicaise #uroonc https://t.co/5SozzprZv3