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Mashup Score: 54UK Biobank - 6 month(s) ago
Enabling the vision of global scientists to improve public health through novel scientific discoveries – UK Biobank
Source: github.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1comparative study of model-centric and data-centric approaches in the development of cardiovascular disease risk prediction models in the UK Biobank - 11 month(s) ago
Abstract. A diverse set of factors influence CVDs, but a systematic investigation of the interplay between these determinants and the contribution of each to CV
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
A comparative study of model-centric and data-centric approaches in the development of #CVD risk prediction models in the #UKBiobank https://t.co/q3hztGY3p6 #EHJDigital #MachineLearning @BruiningNico @rafavidalperez @GerdHindricks https://t.co/Y3z1D9uPgb
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Mashup Score: 0Physical Frailty Shows Association With Incident Parkinson Disease, Modified by Genetic Risk - 1 year(s) ago
Frailty domains such as exhaustion, slow gait speed, low grip strength, and low physical activity were all associated with incident Parkinson disease.
Source: Neurology LiveCategories: Healthcare Professionals, Latest HeadlinesTweet-
Physical #Frailty Shows Association With Incident #Parkinson Disease, Modified by #GeneticRisk https://t.co/1K5jIp62nC via @neurology_live Physical Frailty, Genetic Predisposition, and Incident #ParkinsonDisease https://t.co/ZXopuk08fl via @JAMANeuro #genetics #PRS #UKBiobank… https://t.co/o5Rj3f8iRU https://t.co/alPHIqCzJq
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Mashup Score: 0Association of shift work with incident dementia: a community-based cohort study - BMC Medicine - 1 year(s) ago
Background Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases, but there was no homogeneous evidence of such an association between shift work and incident dementia. This study aimed to investigate whether shift work would increase the risk of dementia in a general population. Methods One hundred seventy thousand…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
#ShiftWork associated with increased risks of #dementia - no further effect of night shift work or genetic profile. #UKBiobank research in #BMCMedicine https://t.co/RjmnUOB0HF https://t.co/7MONqBa9BK
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Mashup Score: 1Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease - BMC Medicine - 1 year(s) ago
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial. Here we examine whether an integrated polygenic risk score improves the prediction of CAD beyond pooled cohort equations. Methods An observation study of 291,305 unrelated White British UK Biobank participants enrolled…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A #Polygenic risk score improves the accuracy of a clinical risk score for #CoronaryArteryDisease Read more about improved predictive accuracy for incident CAD in the #UKBiobank at #BMCMedicine https://t.co/8T5RaacnTj https://t.co/vIhg9IGhRv
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Mashup Score: 3
Objective To examine association of COVID-19 with incident cardiovascular events in 17 871 UK Biobank cases between March 2020 and 2021. Methods COVID-19 cases were defined using health record linkage. Each case was propensity score-matched to two uninfected controls on age, sex, deprivation, body mass index, ethnicity, diabetes, prevalent ischaemic heart disease (IHD), smoking, hypertension and…
Source: HeartCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
New research: COVID-19 infection is linked to a heightened risk of poor cardiovascular health and death, particularly among those whose infection is severe, finds a large #UKBiobank study by @zahra_raisi and colleagues, in the @Heart_BMJ https://t.co/R1XJ00ftG1 #covid https://t.co/60yiqcMtxr
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Mashup Score: 3Association Between Device-Measured Physical Activity and Incident Heart Failure: A Prospective Cohort Study of 94 739 UK Biobank Participants - 2 year(s) ago
Background: Studies of objectively measured physical activity (PA) have investigated acute cardiovascular outcomes but not heart failure (HF), an emerging chronic condition. This study aimed to inves
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#OriginalResearch: In this #UKBiobank analysis of 94,739 participants, higher device-measured physical activity, but especially moderate-intensity activity, was associated with lower r... #HF @MetaMedTeam @jasongill74 @S_parrasoto @bjirapitcha #AHAJournals https://t.co/ypLAaQVOre https://t.co/Nh70jSx3WG
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Mashup Score: 0Efficient estimation of SNP heritability using Gaussian predictive process in large scale cohort studies - 2 year(s) ago
Author summary In recent years, there is an increased interest of estimating heritability from genome-wide SNP data in large scale cohort studies. Here, we propose the PredLMM, a computationally rapid and memory-efficient linear mixed model for heritability estimation. The proposed approach can estimate SNP heritability on Biobank-scale datasets in a fraction of time compared to the existing…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Seal et al present PredLMM: a computationally rapid and memory-efficient linear mixed model for #heritability estimation They demonstrate the method by estimating heritability for quantitative traits using #UKBioBank data #Biostatistics #Genetics https://t.co/BJ3UnRznEb
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Mashup Score: 0
Author summary Polygenic risk score (PRS), an approach to estimate genetic predisposition on disease liability by aggregating the effects across multiple genetic variants, has attracted increasing research interest. While there have been improvements in the predictive performance of PRS for some traits, the applicability of PRS models across a wide range of human traits has not been clear. Here,…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
New research on polygenic risk scores: #Genetics Tanigawa et al use #UKBioBank data to test PRS model performance They find sparse PRS models trained on European ancestry individuals had poor predictive power for individuals of African & Asian ancestry https://t.co/7YiYK5Psiu
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Mashup Score: 8
BACKGROUND: There is a paucity of data regarding the phenotype of dilated cardiomyopathy (DCM) gene variants in the general population. We aimed to determine the frequency and penetrance of DCM-assoc
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#OriginalResearch: #UKBiobank anaylsis of individuals w/ whole exome sequencing -> 7.8% had at least 1 putative pathogenic gene variant for DCM; 1 in 6 carriers exhibited subclinical features on ECG or CMR #AHAJournals https://t.co/ZY8ZO1zov9 https://t.co/g2OcAlVIZ9
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RT @uk_biobank: #UKBiobank is on Github: https://t.co/Rj6Y2evoLU Find code and tools to help you to use the resource. The UKB-RAP-Notebooks…