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Mashup Score: 233Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function - 24 day(s) ago
Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 230Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function - 29 day(s) ago
Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 223Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function - 1 month(s) ago
Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 21Enzyme checkpoint identified in tumor-associated macrophages - 2 month(s) ago
A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in Cellular & Molecular Immunology, shows that the enzyme phosphoglycerate dehydrogenase (PHGDH) acts …
Source: medicalxpress.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 28Cancer mutations converge on a collection of protein assemblies to predict resistance to replication stress - 3 month(s) ago
Abstract. Rapid proliferation is a hallmark of cancer, associated with sensitivity to therapeutics that cause DNA replication stress (RS). Many tumors exhibit drug resistance, however, via molecular pathways that are incompletely understood. Here, we develop an ensemble of predictive models that elucidate how cancer mutations impact the response to common RS-inducing (RSi) agents. The models implement recent advances in deep learning to facilitate multi-drug prediction and mechanistic interpretation. Initial studies in tumor cells identify 41 molecular assemblies that integrate alterations in hundreds of genes for accurate drug response prediction. These cover roles in transcription, repair, cell-cycle checkpoints, and growth signaling, of which 30 are shown by loss-of-function genetic screens to regulate drug sensitivity or replication restart. The model translates to cisplatin-treated cervical cancer patients, highlighting an RTK (receptor tyrosine kinase)-JAK-STAT assembly governing
Source: aacrjournals.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 8Association between pathologic response and survival after neoadjuvant therapy in lung cancer - 6 month(s) ago
Nature Medicine – Analysis of the phase 3 CheckMate 816 trial shows that the depth of pathologic response as assessed by percent residual viable tumor is correlated with event-free survival…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory - 6 month(s) ago
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain stem tumor and the leading cause of pediatric cancer-related death. To date, these tumo…
Source: www.sciencedirect.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 8
University of Toronto (U of T) researchers have found that cancer cells can enhance tumor growth by hijacking enhancer DNA normally used when tissues and organs are formed. The mechanism, called enhancer …
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Collection Details : Oncology Times - 7 month(s) ago
Oncology Times reports essential clinical news for oncologists, hematologists and other cancer care
Source: journals.lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Researchers suggested #tumor heterogeneity in #breastcancer was a big reason why markers like PR and HER2 were being missed that subsequently turned up in surgical specimens. But #biopsy technique was also an issue, they concluded. Listen to the podcast: https://t.co/4oLTAqypYx https://t.co/REyZS2td1x
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Mashup Score: 0Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors - 8 month(s) ago
Nature Communications – Tumor stroma is a key component of the immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). Here, in preclinical PDAC models, the authors…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
New experiments uncover how cancer-associated fibroblasts shape the #tumor microenvironment by “donating” packages of proteins to surrounding cells—hinting that disrupting these communication lines might yield therapeutic benefits. @SciSignal https://t.co/Z1XX7GkT7H https://t.co/waj7HNDHEu