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    Liquid biopsies hold great promise in precision medicine in breast cancer

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    • #ESMO23: What’s the role of #ctDNA in #BreastCancer today? Nicholas Turner: it has opened-up new opportunities for guiding #treatment and detect disease recurrence earlier than standard imaging methods #ESMODailyReporter #BCSM @royalmarsdenNHS 👉https://t.co/rh5qH9P49U https://t.co/8gdvvbFN3T

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    Objective To evaluate the safety and efficacy of tocilizumab (TCZ) in giant cell arteritis (GCA) in a large North American cohort. Methods Patients with GCA treated with TCZ between January 1, 2010, and May 15, 2020, were retrospectively identified. Kaplan-Meier methods were used to estimate time to TCZ discontinuation and time to first relapse after TCZ discontinuation. Poisson regression models were used to compare annualized relapse rates before, during, and after TCZ use. Age- and sex-adjusted risk factors associated with relapse on and off TCZ and development of adverse events of significant interest (AESIs) were examined using Cox models. Results One hundred fourteen patients (60.5% female) were included with mean (SD) age 70.4 (8.2) years. Median duration from GCA diagnosis to TCZ start was 4.5 months. Median overall duration of TCZ treatment was 2.3 years. Relapse rate prior to TCZ start (0.84 relapses/person-year) was 3-fold reduced while on TCZ (0.28 relapses/person-year; P <

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    • Research Article Relapse Risk and Safety of Long-Term Tocilizumab Use Among Patients With Giant Cell Arteritis: A Single-Enterprise Cohort Study 📰 https://t.co/7N2dHPqL2N #giantcellarteritis #tocilizumab #treatment #vasculitis https://t.co/od0nRxB7lS

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    [Original research] [Surgery] Alexandr Muravyev; Ashkhen Shagenovna Galstian; Peter Lavreshin; Sergey Minaev; Roman Juravel; Dmitrii Overchenko; Oleg Lysenko; Oleg Lysenko; Galina Saneeva; Sofia Sergeevna Korablina; Rectovaginal fistulas belong to a rather rare pathology, accounting for about 3 % of all coloproctological diseases and 5 % of all rectal fistulas. This pathology causes significant…

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    • Rectovaginal fistulas. Is there an optimal method of surgical treatment? #some4surgery #treatment #Rectovaginal #fistulas https://t.co/2Tn14bffxO

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    Asthma exacerbations, oral corticosteroid use, and increased asthma severity are associated with adverse perinatal outcomes.1 Asthma biologics have transformed the management of severe asthma (SA), but the clinical trials that served as the basis for regulatory approvals for the biologics excluded pregnant women, and data on their safety and efficacy during pregnancy are limited. Here, we present a case series on the use of benralizumab, an IL-5 receptor antagonist, in pregnant women with SA. We obtained informed consent from all patients.

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    • In Current Issue! #Benralizumab #treatment of #severe #asthma in #pregnancy: A #case #series https://t.co/6ZKpjO3M3k https://t.co/BkXlCDm5fT