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Mashup Score: 0Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis - Nature Communications - 1 year(s) ago
Richter syndrome (RS) is the transformation of chronic lymphocytic leukaemia (CLL) into aggressive lymphoma, in most cases diffuse large B-cell lymphoma (DLBCL). Here, the authors characterize the DNA methylation and transcriptomic profiles of RS samples, find a clonally-related CLL epigenetic imprint, and develop classifiers for “RS-type” de novo DLBCLs.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1
Although similar phenotypically, there is evidence that male and female breast cancer differ in their molecular landscapes. In this systematic review, we consolidated all existing prognostic biomarker data in male breast cancer spanning genetics, transcriptomics, proteomics, and epigenetics, and phenotypic features of prognostic value from articles published over a 29-year period (March 16, 1992,…
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 9pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution - 2 year(s) ago
AbstractAims. Severe acute respiratory syndrome coronavirus-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distres
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 6Clonal diversification and histogenesis of malignant germ cell tumours - Nature Communications - 2 year(s) ago
The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3
Objective To explore the utility of the NanoString platform in elucidating kidney immune transcripts for class III, IV and V lupus nephritis (LN) using a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) kidney biopsy tissue. Methods Immune gene transcript analysis was performed using the NanoString nCounter platform on RNA from LN (n=55), thin basement membrane (TBM) disease…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
Objective To explore the utility of the NanoString platform in elucidating kidney immune transcripts for class III, IV and V lupus nephritis (LN) using a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) kidney biopsy tissue. Methods Immune gene transcript analysis was performed using the NanoString nCounter platform on RNA from LN (n=55), thin basement membrane (TBM) disease…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
Objective To explore the utility of the NanoString platform in elucidating kidney immune transcripts for class III, IV and V lupus nephritis (LN) using a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) kidney biopsy tissue. Methods Immune gene transcript analysis was performed using the NanoString nCounter platform on RNA from LN (n=55), thin basement membrane (TBM) disease…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous recombination deficiency as a key therapeutic vulnerability.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Subtype-specific #genomic, #transcriptomic and functional analyses of #BreastCancer #BrainMetastases highlight homologous recombination deficiency as a key vulnerability #CancerResearch by @Endoadapt @Nicola_Lady @damirvareslija @RCSI_Irl @NatResCancer https://t.co/I1UPfxqqul https://t.co/fRUprSurt9
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Mashup Score: 4The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics - Nature Communications - 2 year(s) ago
The molecular determinants of lung cancer histologic subtypes are not well understood. Here the authors analyze lung cancers of mixed histology and find that histologic subtypes are associated with transcriptomic features rather than genomic profiles in most tumors.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 9Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment - Nature Communications - 3 year(s) ago
Patient-derived xenograft models (PDX) have been extensively used to study the molecular and clinical features of cancers. Here the authors present a cohort of 536 PDX models from 25 cancers, as well as their genomic and evolutionary profiles and their suitability for clinical trials.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet
Recently published: #Transcriptomic and DNA #methylation analysis of #RichterSyndrome reveals #CLL #epigenetic imprint and allows developing a classifier to find this malignancy among #DLBCL cases #leukemia #lymphoma #CancerResearch @natrescancer https://t.co/iXBR5mgtlj https://t.co/GGOIhoM2Xp