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Mashup Score: 0Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis - 11 month(s) ago
Key Points. BRAFV600E alleles are mainly found in myeloid cells at diagnosis of multisystem LCH.After more than 2 years, T cells account for 85% of persistent B
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity - 12 month(s) ago
Key Points. MADD-deficient cytotoxic cells display defect of degranulation, most likely due to impaired activation of RAB27A.Patients with MADD deficiency may h
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Key Points. A small subset of tFL with DLBCL morphology show a PMBL gene expression signature (tFL-PMBLsig-pos).tFL-PMBLsig-pos cases show immunophenotypic and
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression - 1 year(s) ago
Key Points. KLF2 is downregulated by augmented JAK-STAT signaling in PV and ET, leading to upregulated thrombotic gene expression.KLF2 transcript levels in PV a
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression - 1 year(s) ago
Key Points. KLF2 is downregulated by augmented JAK-STAT signaling in PV and ET, leading to upregulated thrombotic gene expression.KLF2 transcript levels in PV a
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study - 1 year(s) ago
Key Points. HSCBs for persistent neutropenia showed recovery or sustained neutrophil improvement in 84% of patients.HSCBs given early and even for moderate neut
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies - 1 year(s) ago
Key Points. Patients with deleterious germ line DDX41 variants experience higher rates of severe acute GVHD after allogeneic stem cell transplant.Posttransplant
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance - 1 year(s) ago
Key Points. Subtle enhanced VWF clearance is present in 20% of patients with low VWF and is associated with an attenuated bleeding phenotype.In patients with lo
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Novel insights into mouse models of ectopic proplatelet release - 1 year(s) ago
Key Points. ADAP-, ARP2/3-, WASp-, and PFN1-deficient MKs show reduced adhesion to collagen.β1-integrin activation and F-actin organization is impaired in ADAP-
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Haptoglobin 1 allele predicts higher serum haptoglobin concentration and lower multiorgan failure risk in sickle cell disease - 1 year(s) ago
Key Points. Adults with SCD and HP 1 allele have lower cell-free hemoglobin-to-HP ratios at steady state and during a vaso-occlusive episode.The HP 1 allele is
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
After more than 2 years, T cells account for 85% of persistent BRAFV600E mutation detected in peripheral blood mononuclear cells. https://t.co/IpfnJ0uwZR #stimulusreport #clinicaltrialsandobservations #myeloidneoplasia https://t.co/6wuoM6ICEF