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    Pancreatic ductal cells transport bicarbonate from blood to pancreatic juice. A study shows that pancreatic cancer retains SLC4A4-mediated bicarbonate import to fuel cancer growth via enhanced glycolysis and establish a pro-tumorigenic immune microenvironment. Targeting SLC4A4 mitigates acidosis and can be combined with checkpoint blockade.

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    • DON’T MISS the News & Views “Bicarbonate transport as a vulnerability in pancreatic cancer” by #StephanieKDougan highlighting work recently published by @LabMazzone in @NatureCancer. #pancreaticcancer #TME https://t.co/P2LEOOcEiU