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Mashup Score: 0Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma - 6 month(s) ago
Analysis of a spectrum of subsolid pulmonary nodules by single-cell RNA sequencing provides insights into the immune regulation and cell–cell interactions in the tumor microenvironment during early lung tumor development.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 11
MSK researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data — and made it freely available to researchers around the world.
Source: www.mskcc.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 6In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies - 9 month(s) ago
AbstractChimeric antigen receptor (CAR) T therapies hold immense promise to revolutionize cancer treatment. Nevertheless, key challenges, primarily in solid tumor settings, continue to hinder the application of this technology. Understanding CAR T-cell mechanism of action, in vivo activity, and clinical implications is essential for harnessing its full therapeutic potential. Single-cell genomics…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 7High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors - Nature Communications - 9 month(s) ago
There is a need for methods that allow the analysis of single-cell long-read sequencing data without depending on known barcode lists or short-read sequencing. Here, the authors develop scNanoGPS, a tool that can independently deconvolute long reads into single cells and single molecules, and apply it on tumour and cell line data.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Largest Human Breast Cell Atlas to Date May Offer Insights Into Mammary Biology - The ASCO Post - 9 month(s) ago
By The ASCO Post Staff Posted: 6/30/2023 11:49:00 AM Last Updated: 6/30/2023 1:21:37 PM Researchers have created the world’s largest and most comprehensive atlas of normal breast tissue—the Human Breast Cell Atlas—which may provide an unprecedented understanding of mammary biology and help identify…
Source: ascopost.comCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia - 9 month(s) ago
Barrett’s esophagus and gastric intestinal metaplasia are molecularly similar precancerous lesions, with epithelial cells being mosaics of gastric and intestinal phenotypes and stromal cells showing features of cancer-associated fibroblasts.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia - 10 month(s) ago
Barrett’s esophagus and gastric intestinal metaplasia are molecularly similar precancerous lesions, with epithelial cells being mosaics of gastric and intestinal phenotypes and stromal cells showing features of cancer-associated fibroblasts.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 6
In this Perspective, Teschendorff and Feinberg describe how single-cell analysis methods based on statistical mechanics can provide valuable insights into developmental phenomena, such as differentiation potency and lineage trajectories, as well as disruption of these processes in cancer.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 1A Better Telescope Gazing at the Transcriptome - 10 month(s) ago
PacBio combines long-read and single-cell technologies to enable deep surveys of RNA-seq space.
Categories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 0Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution - 10 month(s) ago
Single-cell analyses elucidate the chromatin landscape and transcriptional regulation of glioblastoma cellular states and identify a radial glia–like population, providing potential targets to disrupt cell states and improve therapeutic efficacy.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
On the cover of the latest issue— #SingleCell Characterization of #Pulmonary Nodules Implicates Suppression of Immunosurveillance Across Early Stages of Lung #Adenocarcinoma, by Yanagawa et al. https://t.co/siP0REy2nJ @UCLAJCCC https://t.co/97GJpbFHR5