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Mashup Score: 0
Silverberg JI, Guttman-Yassky E, Thaçi D, Irvine AD, Stein Gold L, Blauvelt A, et al. Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis. N Engl J Med 2023;388:1080-91.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Benralizumab treatment of severe asthma in pregnancy: A case series - 6 month(s) ago
Asthma exacerbations, oral corticosteroid use, and increased asthma severity are associated with adverse perinatal outcomes.1 Asthma biologics have transformed the management of severe asthma (SA), but the clinical trials that served as the basis for regulatory approvals for the biologics excluded pregnant women, and data on their safety and efficacy during pregnancy are limited. Here, we present a case series on the use of benralizumab, an IL-5 receptor antagonist, in pregnant women with SA. We obtained informed consent from all patients.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus - 7 month(s) ago
Severe asthma affects about 10% of the population with asthma and is characterized by low lung function and a high count of blood leukocytes, mainly eosinophils. Various definitions are used in clinical practice and in the literature to identify asthma remission: clinical remission, inflammatory remission, and complete remission. This work highlights a consensus for asthma remission using a Delphi method. In the context of the Severe Asthma Network Italy, which accounts for 57 severe asthma centers and more than 2,200 patients, a board of six experts drafted a list of candidate statements in a questionnaire, which has been revised to minimize redundancies and ensure clear and consistent wording for the first round (R1) of the analysis.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3Controversies in Allergy: Are Biologic Treatment Responses in Severe Asthma the Same in Adults and Children? - 7 month(s) ago
The availability of biologic agents for patients with severe asthma has increased dramatically over the last several decades. The absence of direct head-to-head comparative data and relative lack of biomarkers to predict response can make it difficult to choose the right biologic medication for a given patient. Selecting a biologic agent for the pediatric population presents further challenges due to more limited approved biologic agents and fewer clinical trials in children. In addition, the outcome data that are currently available suggest that treatment responses for a given biologic may be different between adult and pediatric patients.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Mepolizumab in Patients With Severe Asthma and Comorbidities: 1-Year REALITI-A Analysis - 7 month(s) ago
Severe asthma is complex; comorbidities may influence disease outcomes.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Omalizumab for severe allergic keratoconjunctivitis: A case series - 8 month(s) ago
Keratoconjunctivitis (KC) is a rare chronic inflammation of the ocular surface. The prevalence is less than 1 in 10,000 people in Europe. Two forms exist: vernal KC (VKC), which begins in childhood, and atopic KC (AKC), which occurs or persists into adulthood and is often associated with atopic dermatitis. Atopic comorbidities such as asthma, atopic dermatitis, allergic rhinitis, and food allergies are frequently associated.1,2
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Enabling adults with severe asthma to exercise: a qualitative examination of the challenges for patients and healthcare professionals. - 8 month(s) ago
Adults living with severe asthma have lower physical activity levels, particularly high intensity physical activity, compared to their healthy peers. Physical inactivity is associated with increased morbidity and mortality.
Source: www.jaci-inpractice.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Uncontrolled and Controlled Severe Asthma in NOVELTY | JAA - 9 month(s) ago
Recommend interventions to achieve good asthma control in more pts with severe asthma – reducing symptom burden & substantial impact on pt health & productivity
Source: www.dovepress.comCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 1Long-term exposure to air pollution and severe COVID-19 in Catalonia: a population-based cohort study - Nature Communications - 10 month(s) ago
In this study, the authors investigate the relationship between exposure to air pollutants and severe COVID-19 disease using data from a cohort of ~5 million people in Catalonia, Spain. They find that long-term exposure to pollutants is associated with a higher risk of COVID-19-related hospitalization, death, intensive care admission, and length of hospital stay.
Source: NatureCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Quantitative and qualitative methods of evaluating response to biologics in severe asthma patients: results from a real-world study. - 1 year(s) ago
Article InfoPublication HistoryAccepted: November 4, 2022Received in revised form: October 24, 2022Received: July 30, 2022Publication stageIn Press Journal Pre-ProofFootnotesFundingThis study has been funded by the grants of the Instituto de Salud Carlos III/Co-funded by the European Regional Development Fund “A way to make…
Categories: Allergy-Immunology, Latest HeadlinesTweet
In Current Issue! #Lebrikizumab #Monotherapy for the #Treatment of #Moderate to #Severe #Atopic #Dermatitis https://t.co/co5pSrVnXS https://t.co/o3LH8u4NjS