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Mashup Score: 0Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis - 11 month(s) ago
Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour necrosis factor alpha biologics. Vnn1 is a pantetheinase that degrades pantetheine to pantothenate (vitamin B5, a precursor of coenzyme A (CoA) biosynthesis) and cysteamine. Vnn1 is overexpressed by inflamed…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis - 11 month(s) ago
Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour necrosis factor alpha biologics. Vnn1 is a pantetheinase that degrades pantetheine to pantothenate (vitamin B5, a precursor of coenzyme A (CoA) biosynthesis) and cysteamine. Vnn1 is overexpressed by inflamed…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 2Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis - 11 month(s) ago
Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour necrosis factor alpha biologics. Vnn1 is a pantetheinase that degrades pantetheine to pantothenate (vitamin B5, a precursor of coenzyme A (CoA) biosynthesis) and cysteamine. Vnn1 is overexpressed by inflamed…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis - 11 month(s) ago
Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour necrosis factor alpha biologics. Vnn1 is a pantetheinase that degrades pantetheine to pantothenate (vitamin B5, a precursor of coenzyme A (CoA) biosynthesis) and cysteamine. Vnn1 is overexpressed by inflamed…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS - 1 year(s) ago
The metagenomic analysis of Guo et al. reveals extensive gut microbiome dysbiosis in patients with myalgic encephalomyelitis/chronic fatigue syndrome and uncovers differences in species abundance, function, and ecological interactions. Reduced abundance of Faecalibacterium prausnitzii is associated with butyrate deficiency and symptom severity, providing insights into the functional consequences…
Source: Cell Host & MicrobeCategories: Healthcare Professionals, Latest HeadlinesTweet-
Deficient #butyrate-producing capacity in the #gut #microbiome is associated with bacterial network disturbances and fatigue symptoms in #MECFS https://t.co/TxPZ3PUHIc #CFS #SCFA #biomarkers "The abundance of F. prausnitzii was inversely associated with #fatigue severity." 3/3 https://t.co/6RdD4su34q
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Mashup Score: 0Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients - 1 year(s) ago
ME/CFS is an understudied multisystemic disease. Xiong et al. present an integrated multi-‘omics analysis comparing ME/CFS patients with matched controls. Short-term disease was characterized by greater gut microbial dysbiosis, particularly a depletion of butyrate-producing microbes; long-term disease was associated with more severe phenotypic and metabolic abnormalities.
Source: Cell Host & MicrobeCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 2Exploring the relationship between gut microbiota and exercise: short-chain fatty acids and their role in metabolism - 3 year(s) ago
The human body is host to a multitude of bacteria, fungi, viruses and other species in the intestine, collectively known as the microbiota. Dietary carbohydrates which bypass digestion and absorption are broken down and fermented by the microbiota to produce short-chain fatty acids (SCFAs). Previous research has established the role of SCFAs in the control of human metabolic pathways. In this…
Categories: Latest Headlines, OrthopedicsTweet
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Mashup Score: 0Try this one thing for optimal health | MDLinx - 3 year(s) ago
Research supports the myriad benefits of exercise on the microbiome.
Source: MDLinxCategories: General Medicine News, Latest HeadlinesTweet
#GUTImage from the paper "Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis" via https://t.co/CI4hhv6pW6 #Colitis #SCFA @achillebro https://t.co/1XJg6a7XLd