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Mashup Score: 7Simulating Ras: 30 years of progress - 9 month(s) ago
Progress in computational simulations of Ras’s movement within lipid bilayers reveal the membrane’s potential directive role on Ras orientation and signaling.
Source: www.cancer.govCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Renin-Angiotensin System Modulation in Adults With COVID-19 - 1 year(s) ago
These 2 randomized clinical trials compare the efficacy and safety of renin-angiotensin system (RAS) modulation using 2 investigational RAS agents, TXA-127 vs placebo and TRV-027 vs placebo, in adults hospitalized with severe COVID-19.
Source: jamanetwork.comCategories: Cardiologists, Latest HeadlinesTweet-
Two additional RCTs also reported in this @JAMA_current issue from #ACTIV4HostTissue fail to show benefit of #RAS modulation with synthetic Ang(1-7) & AngII type 1 receptor-biased ligand on oxygen-free days in hospitalized pts with #COVID19. https://t.co/82IBnj2N0t
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Mashup Score: 0
There has been considerable interest in the potential role of renin-angiotensin system (RAS) inhibitors in patients with COVID-19 given that angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2.1 Because ACE inhibitors and angiotensin receptor blockers (ARBs) may…
Source: jamanetwork.comCategories: Cardiologists, Latest HeadlinesTweet-
Balanced editorial by @UoGHeartFailure @matthewmylee & #JJVMcMurray beautifully summarizing the totality of evidence of #RAS modulation in #COVID19 illness. https://t.co/JYklpgXi7z https://t.co/vY7meWWadK
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Mashup Score: 4Ras protein abundance correlates with Ras isoform mutation patterns in cancer - Oncogene - 1 year(s) ago
Activating mutations of Ras genes are often observed in cancer. The protein products of the three Ras genes are almost identical. However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and RASopathies. We have quantified HRAS, NRAS, KRAS4A and KRAS4B protein abundance across a large panel of cell lines and healthy tissues. We observe…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Learn more about #RAS proteins and their #mutation pattern in #cancer. Here study done by @PriorLab investigates the contributions of Ras isoforms to normal and disease-associated biology. https://t.co/Yy0XfQMeZJ
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Mashup Score: 4Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury - PubMed - 1 year(s) ago
Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury. https://t.co/ulTvq2IAdD #Lysozymenephropathy #EMH #MPNglomerulopathy #ASXL1 #RAS| #CKD #CMML excellent collaboration @MPAlexanderMD Nate Gipe @MayoClinicSOM Nelson Leung!
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Mashup Score: 0Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
FOLFIRI + Cetuximab for #RAS Wild-Type Metastatic #ColorectalCancer: https://t.co/IKSP3IGqRe #OncTwitter #MedTwitter https://t.co/tSL46vClOa
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Mashup Score: 1Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
FOLFIRI + Cetuximab for #RAS Wild-Type Metastatic #ColorectalCancer: https://t.co/IKSP3IGqRe #OncTwitter #MedTwitter https://t.co/fEY4IN74Ok
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Mashup Score: 0Juvenile myelomonocytic leukemia; moving forward - PubMed - 1 year(s) ago
Juvenile myelomonocytic leukemia; moving forward
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Juvenile myelomonocytic leukemia; moving forward. https://t.co/ndtDKhKUmv #JMML #Ras #KMT2A @MayoCancerCare
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Mashup Score: 1A New Drug Could Fight Both COVID and Cancer - 1 year(s) ago
University of Southern California and the Cleveland Clinic Florida Research and Innovation Center researchers have published new research on GRP78, a protein implicated in both COVID-19 and numerous forms of cancer, as well as a new drug that interferes with its effects. While vaccination can pro
Source: SciTechDailyCategories: Healthcare Professionals, Latest HeadlinesTweet-
1) A New Drug Could Fight Both COVID and Cancer - https://t.co/eTR4Ow58wO #RAS #ONCOGENE 2) Targeting #GRP78 suppresses #oncogenic #KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations https://t.co/PvOxEutoNN 3) https://t.co/ewGu2anohT https://t.co/QoXsqUB93J
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Mashup Score: 1Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers - 1 year(s) ago
The complex genomic landscape of RAS-mutant tumors is reflective of selection processes in a cancer lineage–specific and context-dependent manner, highlighting differential therapeutic vulnerabilities that can be clinically translated.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Analysis of NGS data from 66,372 tumors and 51 cancer types from @AACR Project GENIE reveals the complex genomic landscape of #RAS mutant tumors and highlights lineage-specific differential vulnerabilities. https://t.co/RwuV8NcshY @BiagioMd @DrMarkAwad @christine_lovly @ValsamoA https://t.co/O2Hc6BWF3E
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The first crystal structures of the #Ras protein arrived more than thirty years ago. Within a few years, its structure and dynamics were being simulated on computers. Here is an update on decades of progress: https://t.co/6IAOsBs72H