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Mashup Score: 16A novel dual ATM/DNA-PK inhibitor, XRD-0394, potently radiosensitizes and potentiates PARP and topoisomerase I inhibitors - 15 day(s) ago
Abstract. A majority of cancer patients receive radiation therapy as part of their treatment regimens whether using external beam therapy or locally-delivered radioisotopes. While often effective, some tumors are inadequately controlled with radiation and radiation therapy has significant short-term and long-term toxicities for cancer survivors. Insights into molecular mechanisms involved in cellular responses to DNA breaks introduced by radiation or other cancer therapies have been gained in recent years and approaches to manipulate these responses to enhance tumor cell killing or reduce normal tissue toxicity are of great interest. Here, we report the identification and initial characterization of XRD-0394, a potent and specific dual inhibitor of two DNA damage-response kinases, ATM and DNA-PKcs. This orally bioavailable molecule demonstrates significantly enhanced tumor cell kill in the setting of therapeutic ionizing irradiation in vitro and in vivo. XRD-0394 also potentiates the e
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 23The Mutant Wolves of Chernobyl Have Evolved to Survive Cancer - 2 month(s) ago
In the shadow of nuclear disaster, these canines show remarkable resilience to the deadly disease.
Source: apple.newsCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 20Differential Formation of Stress Granules in Radiosensitive and Radioresistant Head and Neck Squamous Cell Carcinoma Cells - 3 month(s) ago
Stress granules (SGs) are cytoplasmic aggregates in which mRNAs and specific proteins are trapped in response to a variety of damaging agents. They participate in the cellular defense mechanisms. Currently, their mechanism of formation in response to ionizing radiation and their role in tumor-cell radiosensitivity remain elusive.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11
Radiation treatment (RT) is a mainstay treatment for many types of cancer. Recommendations for RT and the radiation plan are individualized to each patient, taking into consideration the patient’s tumor pathology, staging, anatomy, and other clinical characteristics. Information on germline mutations and somatic tumor mutations is at present rarely used to guide specific clinical decisions in RT. Many genes, such as ATM, and BRCA1/2, have been identified in the laboratory to confer radiation sensitivity. However, our understanding of the clinical significance of mutations in these genes remains limited and, as individual mutations in such genes can be rare, their impact on tumor response and toxicity remains unclear. Current guidelines, including those from the National Comprehensive Cancer Network (NCCN), provide limited guidance on how genetic results should be integrated into RT recommendations. With an increasing understanding of the molecular underpinning of radiation response, ge
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Activation of STING in Response to Partial-Tumor Radiation Exposure - 7 month(s) ago
To determine the mechanisms involved in partial volume radiation therapy (RT)-induced tumor response.
Source: www.redjournal.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Effect of Conventional and Ultrahigh Dose Rate FLASH Irradiations on Preclinical Tumor Models: A Systematic Analysis - 7 month(s) ago
Compared with conventional dose rate irradiation (CONV), ultrahigh dose rate irradiation (UHDR) has shown superior normal tissue sparing. However, a clinically relevant widening of the therapeutic window by UHDR, termed “FLASH effect,” also depends on the tumor toxicity obtained by UHDR. Based on a combined analysis of published literature, the current study examined the hypothesis of tumor isoefficacy for UHDR versus CONV and aimed to identify potential knowledge gaps to inspire future in vivo studies.
Source: www.redjournal.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5
Remarkable technological advances in recent years led to the development of new radiation therapy methods, such as SABR, SFRT (spatially fractionated radiation therapy), and FLASH-RT (FLASH radiation therapy). The common features of these novel radiation therapy techniques are that they deliver high-dose radiation per fraction to tumors and effectively destroy tumor tissues, and yet they significantly spare adjacent normal tissues. Divergent mechanisms specific to each of these techniques have been proposed to account for their ability to spare normal tissues.
Source: www.redjournal.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2
The goal of our study was to characterize the dynamics of intracellular oxygen during application of radiation at CONV and FLASH dose rates and obtain evidence for or against the oxygen depletion hypothesis as a mechanism of the FLASH effect.
Source: www.redjournal.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0#ASTRO23 Social Champions - American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO) - 8 month(s) ago
#ASTRO23 Social Champions Call for Volunteers: Calling all social savvy #radonc, #MedPhys and #RadBio members! We are looking for volunteers to serve as a Social Champion during the ASTRO 2023 Annual Meeting. The meeting is October 1-4 in San Diego. #ASTRO23 Social Champions serve as Annual Meeting ambassadors on Twitter (X), Instagram or both. Duties include sharing what you’re looking forward…
Source: www.astro.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 6Honorary Membership - American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO) - 9 month(s) ago
Honorary Membership is the highest honor ASTRO bestows upon distinguished cancer researchers and leaders in disciplines other than radiation oncology, radiation physics or radiobiology.
Source: www.astro.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
👉Novel approach of targeting both ATM and DNA-PK for radiosensitization by Mike Kastan, @DKirschMDPhD & Team 🔥 #radbio FREE PDF👇‼️ https://t.co/I9JAjc3d9v