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Mashup Score: 6The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia - Leukemia - 3 year(s) ago
While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (AML). To elucidate the effect of PTPN11 mutations (PTPN11mut) on clinical outcomes, we screened adult…
Source: LeukemiaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1
Key Points. PTPN11 mutations are recurrent alterations in patients with AML and are an independent prognostic factor for poor survival.The deleterious effect is
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2
While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (AML). To elucidate the effect of PTPN11 mutations (PTPN11mut) on clinical outcomes, we screened adult…
Source: LeukemiaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 7
While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (AML). To elucidate the effect of PTPN11 mutations (PTPN11mut) on clinical outcomes, we screened adult…
Source: LeukemiaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1
While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (AML). To elucidate the effect of PTPN11 mutations (PTPN11mut) on clinical outcomes, we screened adult…
Source: LeukemiaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 6Please wait whilst we redirect you - 4 year(s) ago
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Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Histiocytic sarcoma (HS) is a rare, aggressive, and heterogeneous cancer, which remains hard to treat. Here, the authors compare genetic alterations between human HS and spontaneously occurring canin…
Source: Wiley Online LibraryCategories: Hem/Onc News and JournalsTweet
The Clinical impact of #PTPN11 mutations in adults w/acute myeloid leukemia | Leukemia @Malfayez7 @GhayasIssa @TapKadia @garciamanero @DrHKantarjian @GCC_Cortes @doctorpemm @GBorthakur #leusm https://t.co/XjSGdRflfA