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    Pruritus is the sensation of itching; it can be caused by dermatologic and systemic conditions. An exposure history may reveal symptom triggers. A thorough skin examination, including visualization of the finger webs, anogenital region, nails, and scalp, is essential. Primary skin lesions indicate diseased skin, and secondary lesions are reactive and result from skin manipulation, such as…

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    • Top 20 Article of 2022—Pruritus: Diagnosis and Management https://t.co/imnQeq1RPc #familymedicine #Top20AFP2022 #pruritus https://t.co/dd64D6ADzb

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    Prurigo nodularis (PN) is a chronic skin condition characterized by the formation of cutaneous nodules caused by repetitive scratching. Pathogenesis of PN implicates dysregulation of neuroimmunologic circuits that potentiate the itch-scratch cycle.1 Development of unilateral PN after contralateral strokes in various brain regions have been reported,2,3 suggesting a role of the central nervous…

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    • A 56-year-old man presented to the dermatology clinic with a >15 year history of severe #pruritus on the bilateral upper portion of the back and neck with >50 excoriated, hyperpigmented, hyperkeratotic and lichenified papules/nodules consistent with PN... https://t.co/AC3gH5ExQa

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    Growing evidence indicates that transient receptor potential (TRP) channels contribute to different forms of pruritus. However, the endogenous mediators that cause itch through transient receptor potential channels signaling are poorly understood. In this study, we show that genetic deletion or pharmacological antagonism of TRPV4 attenuated itch in a mouse model of psoriasis induced by topical…

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    • De Logu et al reveal the unconventional pathophysiological role for TRPV4 in mediating #pruritus of #psoriasis and an extracellular microRNA: miR-203b-3p that can behave as an itch promoter through activation of 5-HTR2B and TRPV4. @UNI_FIRENZE #TRPV4 https://t.co/AABg09dDGR https://t.co/EtREWK7f9C

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    Linerixibat induced a dose-dependent reduction in itch among patients with primary biliary cholangitis-associated pruritus, according to results published in Clinical Gastroenterology and Hepatology. “Pruritus is commonly associated with primary biliary cholangitis, present in nearly 75% of patients over the disease course,” Cynthia Levy, MD, FAASLD, AGAF, of the University of Miami

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    • #ICYMI from @AGA_CGH: #Linerixibat may relieve #itch in #primarybiliarycholangitis-associated #pruritus #GITwitter #MedTwitter https://t.co/dXT4cBFefJ

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    Linerixibat induced a dose-dependent reduction in itch among patients with primary biliary cholangitis-associated pruritus, according to results published in Clinical Gastroenterology and Hepatology. “Pruritus is commonly associated with primary biliary cholangitis, present in nearly 75% of patients over the disease course,” Cynthia Levy, MD, FAASLD, AGAF, of the University of Miami

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    • #Linerixibat induced a dose-dependent reduction in #itch among patients with #primarybiliarycholangitis-associated #pruritus, according to results published in @AGA_CGH #GITwitter #Medtwitter https://t.co/dXT4cBFefJ