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Mashup Score: 29Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer - 2 day(s) ago
Aneuploidy, defined as the loss and gain of whole and part chromosomes, is a near-ubiquitous feature of cancer genomes, is prognostic, and likely an important determinant of cancer cell biology. In colorectal cancer (CRC), aneuploidy is found in virtually all tumours, including precursor adenomas. However, the temporal evolutionary dynamics that select for aneuploidy remain broadly uncharacterised. Here we perform genomic analysis of 755 samples from a total of 167 patients with colorectal-derived neoplastic lesions that cross-sectionally represent the distinct stages of tumour evolution, and longitudinally track individual tumours through metastasis and treatment. Precancer lesions (adenomas) exhibited low levels of aneuploidy but high intra-tumour heterogeneity, whereas cancers had high aneuploidy but low heterogeneity, indicating that progression is through a genetic bottleneck that suppresses diversity. Individual CRC glands from the same tumour have similar karyotypes, despite pri
Source: www.biorxiv.orgCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 17Human milk affects TLR4 activation and LPS-induced cytokine expression in Caco-2 intestinal epithelial cells - 5 month(s) ago
Background: Human milk (HM) components affect immune cell toll-like receptor 4 (TLR4) signaling. However, studies examining the immunomodulatory impacts of HM on TLR4 signaling in intestinal epithelial cells (IECs) are limited. Methods: This study utili…
Source: www.researchsquare.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 1Following Preprints on medRxiv - 8 month(s) ago
medRxiv – the preprint server for Health Sciences, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: connect.medrxiv.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 16Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice - 10 month(s) ago
The emergence of three distinct highly pathogenic human coronaviruses, SARS-CoV in 2003, MERS-CoV in 2012, and SARS-CoV-2 in 2019, underlines the need to develop broadly active vaccines against the Merbecovirus and Sarbecovirus betacoronavirus subgenera. While SARS-CoV-2 vaccines are highly protective against severe COVID-19 disease, they do not protect against other sarbecoviruses or…
Source: bioRxivCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0Spin Cycle: Do Preprints Overhype Their Findings? - 11 month(s) ago
Preprints offer more than new science; they offer spin as well, according to a recent study. F. Perry Wilson comments.
Source: MedscapeCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 4Framing COVID-19 Preprint Research as Uncertain: A Mixed-Method Study of Public Reactions - 1 year(s) ago
During the COVID-19 pandemic, journalists were encouraged to convey uncertainty surrounding preliminary scientific evidence, including mentioning when research is unpublished or unverified by peer …
Source: Taylor & FrancisCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Neoadjuvant Chemotherapy Underused in Breast Cancer - 1 year(s) ago
If the initial consult is with a surgeon, women are more likely to have up-front surgery for breast cancer. The study was published as a preprint and has not yet been peer reviewed.
Source: MedscapeCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Radiation Medicine at a Crossroads: a Historical Perspective to Consider Future Directions - 1 year(s) ago
As the world shut down in reaction to the COVID-19 pandemic in April 2020, many radiation oncologists began collaborating to revive a decades-old use of ionizing radiation therapy on a clinical trial to try to help with COVID-19 pneumonia. Using low dose radiation therapy (LDRT) for a non-malignant disease based upon historical data has been highly controversial, but this debate has helped revive…
Source: ZenodoCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 6Effectiveness of the Bivalent mRNA Vaccine in Preventing Severe COVID-19 Outcomes: An Observational Cohort Study - 1 year(s) ago
Background: During Late 2022, the SARS-CoV-2 Omicron BA.5 sublineages accounted for most of the sequenced viral genomes worldwide. Bivalent mRNA vaccines contai
Source: papers.ssrn.comCategories: Hem/Oncs, Latest HeadlinesTweet-
.@TheLancet #PrePrint: Arbel & colleagues report the real-world #effectiveness of bivalent mRNA #vaccine in preventing severe #COVID19 outcomes: 81% ⬇️COVID-19 related #hospitalizations 86% ⬇️COVID-19 death #VaccinesWork #Variants #NIHCEAL #ImpSci @SSRN https://t.co/jcstvcyoUv https://t.co/f17TX5MBUb
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Mashup Score: 0
Shifts in research culture, incentives, and technology would be needed for wide adoption
Source: www.science.orgCategories: Healthcare Professionals, Latest HeadlinesTweet
RT @trevoragraham: More distraction: new #preprint we posted a little while ago https://t.co/5niFLLkMK5 looks at somatic copy number #evolu…