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Mashup Score: 1Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes - 7 month(s) ago
BACKGROUND: Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, and cardiovascular outcomes. METHODS: Two hundr
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Evidence of an anti-inflammatory effect of PCSK9 inhibitors within the human atherosclerotic plaque - 8 month(s) ago
Preclinical evidence suggests that proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors hold anti-inflammatory properties independently of their ability to lower LDL-cholesterol (C). However, whether PCSK9 inhibitors exert anti-inflammatory effects within the atherosclerotic plaque in humans is unknown. We explored the impact of PCSK9 inhibitors, used as monotherapy, compared with other lipid-lowering drugs (oLLD) on the expression of inflammatory markers within the plaque, assessing also the subsequent incidence of cardiovascular events.
Source: www.atherosclerosis-journal.comCategories: Cardiologists1, Latest HeadlinesTweet-
RT @SABOURETCardio: Evidence of an anti-inflammatory effect of #PCSK9i within the human atherosclerotic #plaque - https://t.co/CV4cOKZlM0
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Mashup Score: 6Evidence of an anti-inflammatory effect of PCSK9 inhibitors within the human atherosclerotic plaque - 8 month(s) ago
Preclinical evidence suggests that proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors hold anti-inflammatory properties independently of their ability to lower LDL-cholesterol (C). However, whether PCSK9 inhibitors exert anti-inflammatory effects within the atherosclerotic plaque in humans is unknown. We explored the impact of PCSK9 inhibitors, used as monotherapy, compared with other lipid-lowering drugs (oLLD) on the expression of inflammatory markers within the plaque, assessing also the subsequent incidence of cardiovascular events.
Source: www.atherosclerosis-journal.comCategories: Cardiologists, Latest HeadlinesTweet-
Evidence of an anti-inflammatory effect of #PCSK9i within the human atherosclerotic #plaque - https://t.co/CV4cOKZlM0
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Mashup Score: 4Nobel Prize-winning cardiologist on his quest to find and treat vulnerable plaques - 12 month(s) ago
Pioneering cardiologist James Muller, MD, a winner of the Nobel Peace Prize, was one of the chief researchers that developed the concept of vulnerable plaques causing heart attacks. He was recently honored by the American College of Cardiology for his contributions.
Source: Cardiovascular BusinessCategories: Cardiologists, Latest HeadlinesTweet-
Pioneering cardiologist ,co-founder of International Physicians for the Prevention of Nuclear War and Nobel Peace Prize winner ,Dr. James Muller, on his quest to find and treat #vulnerable plaques To treat or not to treat a detected vulnerable #plaque https://t.co/ahVcrMl72x… https://t.co/RzvQTVmlAX
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Mashup Score: 3Heterogeneous plaque-lumen geometry is associated with major adverse cardiovascular events - 1 year(s) ago
AbstractAims. Prospective studies show that only a minority of plaques with higher-risk features develop future major adverse cardiovascular events (MACE), indi
Source: OUP AcademicCategories: Cardiologists, Latest HeadlinesTweet-
Heterogeneous #plaque -lumen geometry is associated with #MACE #LLT https://t.co/WsdjFMw6mN
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Mashup Score: 3Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion - 1 year(s) ago
AbstractAims. Endothelial erosion of plaques is responsible for ∼30% of acute coronary syndromes (ACS). Smoking is a risk factor for plaque erosion, which most
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Where there’s smoke, there’s #plaque erosion🚬 #Cigarette smoke stimulation of Nrf2 destabilizes plaques through OSGIN1&2 & HSP70, leading to #AcuteCoronarySyndromes ❤️🩹 https://t.co/d6tAIQKxwh @CVR_TomaszGuzik @glenpyle @DrMikeDrozd #atherosclerosis #CardiovascularResearch https://t.co/jN7xJZOIe9
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Mashup Score: 11Long-term prognostic implications of hemodynamic and plaque assessment using coronary CT angiography - 1 year(s) ago
Hemodynamic and plaque characteristics can be analyzed using coronary CT angiography (CTA). We aimed to explore long-term prognostic implications of hemodynamic and plaque characteristics using coronary CT angiography (CTA).
Source: AtherosclerosisCategories: Cardiologists, Latest HeadlinesTweet-
Long-term prognostic implications of hemodynamic and #plaque assessment using #yesCCT https://t.co/OjyYvU24yB
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Mashup Score: 15The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques - Nature Aging - 1 year(s) ago
Kabir et al. show that aged bone marrow induces smooth muscle cell (SMC) polyclonality in atherosclerosis. Decreased TET2 levels in aged myeloid cells lead to silenced integrin β3, resulting in increased TNFα signaling and the expansion of multiple SMC progenitors.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @medical_xpress: Study finds aging of #bonemarrow accelerates arterial #plaque formation @yale @NatureAging https://t.co/ObmV4nVYe3 http…
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Study finds aging of #bonemarrow accelerates arterial #plaque formation @yale @NatureAging https://t.co/ObmV4nVYe3 https://t.co/fnYYyz0Izl
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Mashup Score: 0
AbstractAims. Low wall shear stress (WSS) is acknowledged to play a role in plaque development through its influence on local endothelial function. Also, lipid-
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
New near-infrared spectroscopy (NIRS) and optical coherence tomography (OCT) study in #CardiovascularResearch reveals a synergistic effect on #plaque progression between low wall shear stress and #lipid-rich plaques https://t.co/LqCFHqoR14 @CVR_TomaszGuzik @DrMikeDrozd @glenpyle https://t.co/QdUijydse9
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Mashup Score: 3Nicotine exacerbates endothelial dysfunction and drives atherosclerosis via extracellular vesicle-miRNA - 1 year(s) ago
AbstractAims. Nicotine, a major component of tobacco, is an important factor contributing to atherosclerosis. However, the molecular mechanisms underlying the l
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Where there's smoke🚬, there's fire🔥 #Nicotine⬆️#ExtracellularVesicles containing miR-155 to damage endothelial cells & promote #plaque formation https://t.co/gRFlb2O0Da @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #inflammation #atherosclerosis #smoking #CardiovascularResearch https://t.co/JKCXQSlUyt
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Theofilatos et al found that proteomic signatures of #plaque composition were found to predict long-term, adverse CV events, improving risk stratification for patients with advanced #atherosclerosis. https://t.co/wl0QYIVJM6 @k_theofilatos @Vascular_Prot @swvanderlaaan https://t.co/uAvvTHcATf