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    In a phase II trial reported in The New England Journal of Medicine, Eric Bouffet, MD, and colleagues found that the combination of dabrafenib and trametinib produced a higher objective response rate vs standard chemotherapy in the first-line treatment of pediatric patients with low-grade glioma and BRAF V600 mutations. In the open-label trial, 110 patients from sites in 20 countries were randomly assigned 2:1 between September 2018 and December 2020 to receive dabrafenib/trametinib (n = 73) or standard

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    • Pediatric BRAF V600–Mutated Low-Grade Glioma: First-Line Therapy https://t.co/1eenkHnVH4 #btsm #glioma #oncology #pedonc

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    On September 26, the U.S. Food and Drug Administration (FDA) approved bosutinib (Bosulif) for pediatric patients aged 1 year and older with chronic-phase, Philadelphia chromosome–positive chronic myelogenous leukemia (CML) that is newly diagnosed or resistant or intolerant to prior therapy. The FDA also approved a new capsule dosage form, available in 50-mg and 100-mg doses. Efficacy was evaluated in the BCHILD trial (ClinicalTrials.gov identifier NCT04258943), a mult icenter, nonrandomized, open-label

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    • .@US_FDA Approves Therapy for Pediatric CML https://t.co/EDgGxhdH4M #leusm #leukemia #pedonc @FDAOncology

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    Childhood Cancer Awareness Month is recognized every September to help shine a light on the realities of pediatric cancer and raise awareness of the important work being done to make a difference for the children who are diagnosed with cancer. September 15 also marked the start of Hispanic Heritage Month. As a Latin-American physician who has spent more than 33 years in pediatric care, the intersection of these two campaigns holds significant import ance to my identity as a native of San Francisco and my

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    • Decentralized Care Models Empower Equitable Pediatric Cancer Treatment, by Norman J. Lacayo, MD https://t.co/XunPlLWrWd #pediatriccancer #pedonc @StanfordMed