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Mashup Score: 2Against All Odds | Cancer Today - 5 month(s) ago
At age 26, Manny Garcia was diagnosed with stage IV pancreatic cancer, but after immunotherapy treatment reached remission.
Source: www.cancertodaymag.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1Ohio State pancreatic cancer researchers are focused on earlier identification of risk and treatment choices - 1 year(s) ago
By increasing understanding of pancreatic cancer before treatment begins, Ohio State doctors could improve outcomes for patients.
Source: The James - OSUCCCCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Hosein et al. discuss the current therapeutic landscape in pancreatic cancer as well as the translational and clinical implications and the challenges to overcome.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer - Nature Cancer - 1 year(s) ago
Singh and colleagues show that PDAC phenotypic plasticity is regulated via AP1 enhancer remodeling and modulated by TNF-α+ macrophages and pharmacological inhibition of the BRD4–cJUN–CCL2–TNF-α axis restores favorable PDAC subtypes and prognosis.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Halbrook et al. report two metabolic subgroups of pancreatic ductal adenocarcinoma cells defined by differential integrated stress response and asparagine production that permit symbiosis and phenformin resistance.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Ting and colleagues report the safety and efficacy of combined radiation and immunotherapy in a phase II trial on patients with MSS colorectal or pancreatic cancer and observe that disease control correlates with higher repetitive RNA transcription.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4
David and colleagues uncover an inflammation-activated, progenitor-derived enhancer network hijacked by mutant Kras during pancreatic cancer initiation.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth - Nature Cancer - 1 year(s) ago
Yuan et al. demonstrate that cancer-associated fibroblasts in the pancreatic tumor microenvironment secrete nucleosides through autophagy in an NUFIP1-dependent manner, thereby inducing glucose consumption under glutamine-deprived conditions and promoting tumor growth.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors - Nature Cancer - 1 year(s) ago
Winter and colleagues demonstrate that metabolic adaptation to nutrient stress in the tumor microenvironment of pancreatic cancer leads to a dependency on IDH1, which is therapeutically actionable regardless of IDH1 mutation status.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Saur and colleagues perform a high-throughput combinatorial drug screen and identify a synergistic combination between nintedanib and trametinib that sensitizes mesenchymal PDAC to immune checkpoint blockade.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
November is #PancreaticCancerAwarenessMonth. The median age for a pancreatic cancer diagnosis is 70 years old, but Manny Garcia was diagnosed at 26. Thanks to an experimental immunotherapy, he is now in remission. He shares his story in @CancerTodayMag: https://t.co/Aj2mNCGaKZ