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Mashup Score: 10A Seemingly Benign Pancreatic Cyst With an Unsettling Trend of Enlarging Size and Associated Symptoms - 3 day(s) ago
Question: A 62-year-old woman was incidentally diagnosed with a well circumscribed hypoattenuating cyst in the head of the pancreas during a computed tomographic (CT) scan while being evaluated for nonspecific colitis. Subsequent magnetic resonance imaging confirmed the presence of a well circumscribed, T1-hypointense, T2-hyperintense cystic mass measuring 3.5 × 3.3 cm in the head of the pancreas (Figure A). Mild dilation was observed in the common bile duct secondary to an earlier cholecystectomy.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1
Entosis plays a pivotal role in pancreatic ductal adenocarcinoma progression by generating cancer cells with enhanced malignant behavior. Targeting the entotic processes of pancreatic ductal adenocarcinoma cells may be an optional therapeutic strategy.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet-
Cell-in-Cell–Mediated Entosis Reveals a Progressive Mechanism in #Pancreatic Cancer ➡️ https://t.co/f0fkn4R8WK https://t.co/0SR9FGFRzq
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Mashup Score: 13The Natural Disease Course of Pancreatic Cyst–Associated Neoplasia, Dysplasia, and Ductal Adenocarcinoma: Results of a Microsimulation Model - 5 month(s) ago
Estimates on the progression of precursor lesions to pancreatic cancer (PC) are scarce. We used microsimulation modeling to gain insight into the natural disease course of PC and its precursors. This information is pivotal to explore the efficacy of PC screening.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet-
Editor's Essential Reading ➡️ The Natural Disease Course of #Pancreatic Cyst–Associated Neoplasia, Dysplasia, and Ductal Adenocarcinoma https://t.co/H5Z8CT8Z88 https://t.co/gxZTAFcQBF
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Mashup Score: 2S2001 | SWOG - 6 month(s) ago
Disease Related Criteriaa. Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the Baseline Tumor Assessment Form.b. Patients must have one of the following mutations: germline mutation in BRCA 1 or 2 that was tested in a CLIA…
Source: www.swog.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
S2001 tests olaparib w/wo pembrolizumab as maintenance therapy in patients w germline BRCA mutations who have metastatic #pancreatic adenocarcinoma that responded to chemo in the last 30 days. https://t.co/YpSBVrWm7c @NRGonc Study Champion: @NiuSanford @UTSWNews #pancsm https://t.co/K3djWg1iU8
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Mashup Score: 6S2001 | SWOG - 6 month(s) ago
Disease Related Criteriaa. Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the Baseline Tumor Assessment Form.b. Patients must have one of the following mutations: germline mutation in BRCA 1 or 2 that was tested in a CLIA…
Source: www.swog.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
.@SWOG S2001 is for patients with #pancreatic adenocarcinoma that responded to first-line platinum-based chemotherapy and who have a germline mutation in BRCA1 or BRCA2. https://t.co/YpSBVrWm7c Co-PI: @MPishvaian @hopkinskimmel @Alliance_org https://t.co/sbF7hsOyxV
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Mashup Score: 0S2001 | SWOG - 6 month(s) ago
Disease Related Criteriaa. Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the Baseline Tumor Assessment Form.b. Patients must have one of the following mutations: germline mutation in BRCA 1 or 2 that was tested in a CLIA…
Source: www.swog.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
The @SWOG S2001 study is enrolling patients with metastatic #pancreatic cancer who have a germline BRCA mutation. It randomizes to olaparib alone vs olaparib plus pembrolizumab. https://t.co/YpSBVrWm7c @theNCI PI: Vincent Chung, MD @CityofHope @TheCTSU @NCICTEP_ClinRes https://t.co/0ApYmf5HYH
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Mashup Score: 1Endoscopic Ultrasound-guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma - 7 month(s) ago
Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a safe and effective treatment for pancreatic neuroendocrine tumors. We aimed to compare EUS-RFA and surgical resection for the treatment of pancreatic insulinoma (PI).
Source: www.cghjournal.orgCategories: Gastroenterology, Latest HeadlinesTweet-
Study examines #endoscopic ultrasound-guided radiofrequency ablation versus surgical resection for treatment of #pancreatic insulinoma. Learn more at https://t.co/HfeuySJ7Tl https://t.co/qvgu2sN5Q5
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Mashup Score: 0Adding The Drug Pembrolizumab to Usual Treatment for People with Advanced Pancreatic Cancer and a BRCA Gene Change | SWOG - 7 month(s) ago
Clinical Trial Summary (S2001) What is the purpose of this clinical trial? This study tests treatment for pancreatic cancer that has spread. It is for people with a BRCA1 or BRCA2 gene change (mutation) that is inherited (passed down in a family). After initial chemotherapy treatment for pancreatic cancer, doctors may…
Source: www.swog.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Olaparib is FDA-approved to treat advanced #pancreatic cancer after initial #chemotherapy for people with BRCA gene mutations. Study S2001 adds pembrolizumab to olaparib for these patients. Learn more at https://t.co/RD8HV4AXah. Or call 1-800-4-CANCER. Ask about S2001. #pancsm https://t.co/OhFtZkTSzM
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Mashup Score: 0Adding The Drug Pembrolizumab to Usual Treatment for People with Advanced Pancreatic Cancer and a BRCA Gene Change | SWOG - 7 month(s) ago
Clinical Trial Summary (S2001) What is the purpose of this clinical trial? This study tests treatment for pancreatic cancer that has spread. It is for people with a BRCA1 or BRCA2 gene change (mutation) that is inherited (passed down in a family). After initial chemotherapy treatment for pancreatic cancer, doctors may…
Source: www.swog.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
S2001 is a study for people with metastatic #pancreatic #cancer who have an inherited BRCA1 or BRCA2 gene change (mutation). Learn more at https://t.co/RD8HV4AXah. Or call 1-800-4-CANCER. Ask about S2001. #pancsm @ARosen380 @PanCAN https://t.co/wNl4cb9qZ5
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Mashup Score: 0Keeping IPMNs in Check: A Novel Role for the Transcription Factor NKX6-2 in Preserving an Indolent Cell Identity in Pancreatic Cystic Lesions - 8 month(s) ago
Summary:. In this issue of Cancer Discovery, Sans and colleagues identify the transcription factor NKX6-2 as a principal element in maintaining the low-grade gastric cell phenotype of intraductal papillary mucinous neoplasms (IPMN) in the pancreas. Their discoveries in patient cohorts and dissection in animal models provide a novel molecular understanding underpinning IPMN differentiation, with implications for risk stratification and therapeutic intervention in pancreatic cancer.See related article by Sans et al., p. 1844 (7).
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#ICYMI from the latest issue— Keeping IPMNs in check: A novel role for the transcription factor NKX6-2 in preserving an indolent cell identity in #pancreatic cystic lesions, by @AviadBenShmuel and @shouval. https://t.co/3yPTkqdtY6 @shouval_lab @WeizmannScience https://t.co/kFeNI9K7bl
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A Seemingly Benign #Pancreatic Cyst With an Unsettling Trend of Enlarging Size and Associated Symptoms ➡️ https://t.co/5w3Ixtlum1 https://t.co/4sptsfohk1