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Mashup Score: 1Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study - 1 year(s) ago
Background Approximately 10% of gastric cancers (GCs) are associated with strong familial clustering and can be attributed to genetic predisposition. Homologous recombination deficiency (HRD) leads to genomic instability and accumulation of genetic variations, playing an important role in the development and progression of cancer. We aimed to delineate the germline mutation characteristics of…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 4Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Germline pathogenic variants (GPVs) in the cancer predisposition genes BRCA1 , BRCA2 , MLH1 , MSH2 , MSH6 , BRIP1 , PALB2 , RAD51D and RAD51C are identified in approximately 15% of patients with ovarian cancer (OC). While there are clear guidelines around clinical management of cancer risk in patients with GPV in BRCA1 , BRCA2 , MLH1 , MSH2 and MSH6 , there are few guidelines on how to manage the…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0
Telli and colleagues present a phase II clinical trial of the PARP inhibitor talazoparib in patients with solid tumors and show that the drug has activity in patients with breast cancer with mutations in other homologous recombination pathway genes beyond BRCA1 and BRCA2.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Telli and colleagues present a phase II clinical trial of the PARP inhibitor talazoparib in patients with solid tumors and show that the drug has activity in patients with breast cancer with mutations in other homologous recombination pathway genes beyond BRCA1 and BRCA2.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Finally online in @NatureCancer phase II data showing the clinical activity of single agent #talazoparib in patients without germline #BRCA PVs but with other defects in homologous recombination genes like germline #PALB2 PVs @OncoAlert #PARPi #bcsm Link: https://t.co/aOaJsfFxu1 https://t.co/jaqTxix19m
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Mashup Score: 0Contribution of large genomic rearrangements in PALB2 to familial breast cancer: implications for genetic testing - 2 year(s) ago
Background PALB2 is the most important contributor to familial breast cancer after BRCA1 and BRCA2 . Large genomic rearrangements (LGRs) in BRCA1 and BRCA2 are routinely assessed in clinical testing and are a significant contributor to the yield of actionable findings. In contrast, the contribution of LGRs in PALB2 has not been systematically studied. Methods We performed targeted sequencing and…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 12For Less Familiar Gene Mutations Linked to Breast Cancer, Research Aims to Create Screening Guidelines - 2 year(s) ago
Computer models suggest breast cancer screening guidelines for people with mutations in the genes ATM, CHEK2, and PALB2.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
e16757 Background: Immune checkpoint inhibitors (ICIs) have not shown meaningful clinical activity in unselected pts with pancreaticobiliary cancer. DDR-deficient tumors have increased genomic instability, including increased tumor mutation burden (TMB), more tumor-infiltrating immune cells, and enrichment of a T cell-inflamed signature. We hypothesized that pts with DDR deficiency may be…
Source: Journal of Clinical OncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Along the same question of CTLA4 /PD1βοΈ: IPI/NIVO for #pancreascancer with germline #BRCA #RAD51 #PALB2 #PANCSM Do we have updates/off-label or ongoing studies to thisππΎ@ASCO @JCO_ASCO? @PeterHoseinMD presented on 8 pts. Durable responses. @OncoAlert https://t.co/AzGmjIcZoj https://t.co/jwb82qGU4H
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In the fight for improved treatments for patients with metastatic #breastcancer, a new study has found that #talazoparib is effective in treating patients with #PALB2 mutations: https://t.co/eyFf8MItvp #BCSM https://t.co/WSpnQPFJsI