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Mashup Score: 0
Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection
Source: boneandjoint.org.ukCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia - 2 year(s) ago
Kynurenine secreted by acute myeloid leukemia cells activates the serotonin receptor 1b in osteoblasts to drive leukemia through the acute-phase protein serum amyloid A (SAA), with an increase in both kynurenine and SAA seen in mouse models and patient samples.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the April issue: Subversion of #serotonin-receptor signaling in #osteoblasts by kynurenine drives acute myeloid #leukemia by @MG_Ph_D, Stavroula Kousteni, et al. https://t.co/wk7taoI66m @columbiacancer @ColumbiaMed @CSCIColumbia https://t.co/7TZVOTLnOb
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Mashup Score: 2Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia - 2 year(s) ago
Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer growth. Molecular delineation and targeting of such malignant-cell non-autonomous pathways may help overcome resistance to targeted-therapies. Herein we leverage genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia (AML) exploits peripheral…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Subversion of #serotonin-receptor signaling in #osteoblasts by kynurenine drives acute myeloid #leukemia. https://t.co/4o0uVsEo7q by @MG_Ph_D, Stavroula Kousteni, and colleagues @columbiacancer @ColumbiaMed https://t.co/bP565VPbZR
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Mashup Score: 0The role of osteoblasts in energy homeostasis - 3 year(s) ago
Osteoblasts synthesize bone matrix and work in harmony with bone-resorbing osteoclasts in a continuous bone remodelling cycle. This Review discusses three known osteoblast-secreted endocrine factors (osteocalcin, lipocalin and sclerostin) and highlights how these hormones integrate the metabolic requirements of bone formation with respect to whole-body metabolism.
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet-
Naomi Dirckx, Megan C. Moorer, Thomas L. Clemens & @RyanCRiddle explore the role of #osteoblasts in #energy homeostasis (£) https://t.co/NLLzyTvDGE https://t.co/7SztzeDuDu
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Mashup Score: 2The role of osteoblasts in energy homeostasis - 4 year(s) ago
Osteoblasts synthesize bone matrix and work in harmony with bone-resorbing osteoclasts in a continuous bone remodelling cycle. This Review discusses three known osteoblast-secreted endocrine factors (osteocalcin, lipocalin and sclerostin) and highlights how these hormones integrate the metabolic requirements of bone formation with respect to whole-body metabolism.
Source: Nature Reviews EndocrinologyCategories: Endocrinology, Latest HeadlinesTweet-
Naomi Dirckx, Megan Moorer, Thomas Clemens & Ryan Riddle review the role of #osteoblasts in #energy homeostasis https://t.co/NLLzyTe2i4 (£) #bone https://t.co/1cGcHEBeGw
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Mashup Score: 0JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function - 4 year(s) ago
Inhibitors of Janus kinase (JAK) reduce inflammation and are approved to treat rheumatoid arthritis; however, the direct effects of inhibitors on bone remain unclear. Adam et al. found that JAK inhibitors increased bone mass in mice under homeostatic conditions and mitigated bone loss in a mouse model of osteoporosis. Mice with inflammatory bone loss mimicking rheumatoid arthritis had reduced…
Source: Science Translational MedicineCategories: EndocrinologyTweet-
JAK inhibitors increase the activity of #osteoblasts and have osteoanabolic potential https://t.co/GYAxTG8hET #osteoporosis
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Intracellular Staphylococcus (S.) aureus infection impaired osteoblast metabolism and function. However, treatment with low dosage of rifampicin eradicated the intracellular S. aureus. #Infection #Osteoblasts #Orthopedics #BJR https://t.co/ZxTcMr6YPq https://t.co/yDg2cD3p01