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Mashup Score: 44
Long-term physical activity induces structural, functional and electrical changes in the heart, reflecting adaptive physiological responses to the increased cardiac output during exercise.1 These effects are usually reversible after short detraining periods. Differentiating between exercise-induced cardiac changes and early signs of cardiac pathology often poses a clinical challenge, especially in so-called ‘grey zone’ (borderline) cases.1 This editorial presents the rationale and considerations for a period of detraining in the diagnostic evaluation of athletes with premature ventricular beats (PVBs). Evidence suggests that intense physical exercise and training may increase the propensity to develop arrhythmias.2 Studies have shown that endurance athletes may exhibit a higher incidence of bradyarrhythmias and atrial fibrillation, while the association between physical training and ventricular arrhythmias remains debated.2 The mechanisms linking the athlete’s heart to arrhythmias, whi
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 9
Background: Numerous graft options are available when undertaking anterior cruciate ligament (ACL) reconstruction (ACLR), although a lack of high-quality eviden…
Source: journals.sagepub.comCategories: General Medicine News, OrthopedicsTweet
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Mashup Score: 2
The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which …
Source: acamh.onlinelibrary.wiley.comCategories: General Medicine News, PediatricsTweet
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Mashup Score: 0Cancer epigenetics in clinical practice - 8 day(s) ago
Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute…
Categories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 42Pelvic floor muscle training in female functional fitness exercisers: an assessor-blinded randomised controlled trial - 8 day(s) ago
Objective Stress urinary incontinence (SUI) is common among females during functional fitness training, such as CrossFit. The aim of this study was to assess the effect of pelvic floor muscle training (PFMT) on SUI in female functional fitness exercisers. Methods This was an assessor-blinded randomised controlled trial with a PFMT group (n=22) and a control group (n=25). The PFMT group followed a 16-week home-training programme with 3 sets of 8–12 maximum pelvic floor muscle (PFM) contractions daily and weekly follow-up/reminders by phone. The primary outcome was change in a total score of the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI-SF). The secondary outcomes were perceived change of symptoms of SUI, change of PFM strength measured by vaginal manometry and symptoms of anal incontinence (AI) and pelvic organ prolapse (POP). Results 47 women, mean age of 33.5 years (SD: 8.1), participated. At 16 weeks, there was a mean difference
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 3
Keyes’ and Platt’s (The Journal of Child Psychology and Psychiatry, 2023) review provides much-needed systematic evidence about why internalizing symptoms have increased and it clarifies the role of …
Source: acamh.onlinelibrary.wiley.comCategories: General Medicine News, PediatricsTweet
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Mashup Score: 6Social determinants of health and US cancer screening interventions: A systematic review - 10 day(s) ago
There remains a need to synthesize linkages between social determinants of health (SDOH) and cancer screening to reduce persistent inequities contributing to the US cancer burden. The authors conduct…
Categories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 46
Abstract. Since 2014, the National Cancer Institute (NCI) has launched a series of data commons as part of the Cancer Research Data Commons (CRDC) ecosystem housing genomic, proteomic, imaging, and clinical data to support cancer research and promote data sharing of NCI-funded studies. This review describes each data commons (Genomic Data Commons, Proteomic Data Commons, Integrated Canine Data Commons, Cancer Data Service, Imaging Data Commons, and Clinical and Translational Data Commons), including their unique and shared features, accomplishments, and challenges. Also discussed is how the CRDC data commons implement Findable, Accessible, Interoperable, Reusable (FAIR) principles and promote data sharing in support of the new NIH Data Management and Sharing Policy.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
What are @theNCI Cancer Research Data Commons & how can you use these cloud based repositories to accelerate research? A series of #OpenAccess articles in @CR_AACR including: An introduction to the Data Commons and the six specialized DCs - https://t.co/iIEl9jQLMV Core… https://t.co/SFugV8UXaI https://t.co/UIM77GgdV2
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Mashup Score: 19A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation - 10 day(s) ago
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate the development of improved biomarkers and treatments.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 15
Abstract. Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1–mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
⚠️ Premature ventricular beats in athletes: to detrain or not to detrain? ❤️ NEW #OpenAccess editorial including a useful flow diagram for the clinical work up of athletes with PVB ⬇️ READ 👉 https://t.co/swaRPoc2YN https://t.co/GXusN4gzaM