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Mashup Score: 5
PURPOSE Despite fibroblast growth factor receptor (FGFR) inhibitors being approved in tumor types with select FGFR rearrangements or gene mutations, amplifications of FGFR represent the most common FGFR alteration across malignancies. Subprotocol K1 (EAY131-K1) of the National Cancer Institute-MATCH platform trial was designed to evaluate the antitumor efficacy of the oral FGFR1-4 inhibitor, erdafitinib, in patients with tumors harboring FGFR1-4 amplification. METHODS EAY131-K1 was an open-label, single-arm, phase II study with central confirmation of presence of FGFR1-4 amplification in tumors. Patients with urothelial carcinoma were excluded. Enrolled patients received oral erdafitinib at a starting dose of 8 mg once daily continuously with escalation to 9 mg once daily continuously, on the basis of predefined time point assessments of phosphate levels, until disease progression or intolerable toxicity. The primary end point was centrally assessed objective response rate (ORR), with
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Tools on the Horizon for Managing Posttransplant cSCC Risk - 2 month(s) ago
Organ transplant recipients have a 200-fold increased incidence of keratinocyte carcinoma compared with immunocompetent individuals, and cSCC accounts for 80% of skin cancers in those recipients.
Source: www.medscape.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Does Eliminating Alcohol Intake Lower Cancer Risk? - 3 month(s) ago
When it comes to the link, a new report from WHO revealed limited or inadequate evidence to suggest consuming less alcohol or stopping altogether reduced the risk for most cancers.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Study Reveals Disparities in CRC Biomarker Testing Trends - 3 month(s) ago
Testing trends are consistent with guideline recommendations and FDA approvals, but demographic disparities exist.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2Patients State More Accurate Prognosis When in Poor Health - 3 month(s) ago
Dr Maurie Markman discusses a paper focused on the controversial oncology topic of prognosis beliefs among patients with metastatic cancer.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2Healthier Lifestyle Linked to Lower Risk for Cancer Death - 3 month(s) ago
A multicenter cohort study found that adhering to a healthy lifestyle including limiting alcohol intake and moderate physical activity could reduce cancer survivors’ risk for mortality.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Colorectal Cancer Risk Increasing Across Successive Birth Cohorts - 3 month(s) ago
Colorectal cancer incidence is increasing in people aged 50-54 and younger than 50, and a prior decrease in incidence is flattening in individuals aged 55-74.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet-
CRC epidemiology is changing due to a birth cohort effect, also called birth cohort CRC — the observed phenomena of the rising risk for CRC across successive generations of people born in 1960 and later — according to a new narrative review. #OncTwitter https://t.co/oBdOLx3NHR https://t.co/v9wAwaRPay
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Mashup Score: 0Even Intentional Weight Loss Linked With Cancer - 3 month(s) ago
In a recent study, one type of cancer was particularly common among people who had recently lost weight.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Call to Action: Fix the Drug Shortages to Save Patients - 3 month(s) ago
Dr Maurie Markman discusses widespread shortages of anticancer chemotherapeutic agents.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0All In: Two Cancers, One Surgical Team Who's Not Giving Up - 3 month(s) ago
Surgeons know not to count on miracles, but sometimes they can happen. Our cameras follow a surgical team as they work together to treat a patient with an uncertain outcome.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
Ugh, I was really hoping this would be positive. Anyone have ideas on 🎯FGFR amplification ?#onctwitter Phase II Study of Erdafitinib in Patients With Tumors With FGFR Amplifications: Results From the NCI-MATCH ECOG-ACRIN Trial| JCO Precision Oncology https://t.co/XSIhiXrhHT