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Mashup Score: 4
NOTCH1 mutations have opposing effects on cell fitness in normal and cancerous esophageal epithelia.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Oscar Silva, Allison Shaw; Nonleukemic T/B mixed phenotype acute leukemia with PHF6 and NOTCH1 mutations, Blood, Volume 138, Issue 9, 2 September 2021, Pages 81
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Nonleukemic T/B mixed phenotype acute #Leukemia with #PHF6 and #NOTCH1 mutations👇 https://t.co/ciVyqyM53x @StanfordMed #MPAL https://t.co/cR4SEFYLOx
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Mashup Score: 3
The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to target this circuit is poorly defined. Bromodomain-containing protein 4 (BRD4) is implicated to have a role in the transcriptional regulation of oncogenes MYC and targets downstream of…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Targeting the #NOTCH1-#MYC-#CD44 axis in leukemia-initiating cells in T-ALL | @LeukemiaJnl | Led by .@GBorthakur & team | @DrHKantarjian @MDAndersonNews #endcancer #leusm #lymsm #BETi #BRDi #BRD4 https://t.co/HPIFSe9gqz
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Mashup Score: 0Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria - 3 year(s) ago
Rationale: Glomerular capillaries are lined with a highly specialized fenestrated endothelium and contribute to the glomerular filtration barrier. The Notch signaling pathway is involved in regulatio
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Li and colleagues found that endothelial #Notch1 activation increased permeability of human #renal glomerular #EndothelialCells through decreased VE-cadherin expression and led to #albuminuria a sign of kidney disease. Learn more at https://t.co/ejrfd78dKY @tradewindbio https://t.co/EebSaUMKN4
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Mashup Score: 3Circulation Research | AHA/ASA Journals - 3 year(s) ago
© American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is qualified 501(c)(3) tax-exempt organization.*Red Dress ™ DHHS, Go Red ™; AHA; National Wear Red Day ® is registered trademark. …
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
@CircRes March 5th Issue is Out! https://t.co/oLIc1T1jNP Cover: Immunofluorescence staining showing increased permeability of human #renal glomerular #EndothelialCells through decreased VE-cadherin expression from #Notch1 activation; cell membrane-green, nuclei-blue https://t.co/IC7V0iiMRw
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Mashup Score: 0Inhibition of Notch1 reverses EMT and chemoresistance to cisplatin via direct downregulation of MCAM in triple‐negative breast cancer cells - 4 year(s) ago
What’s new? Epithelial‐mesenchymal transition (EMT) likely contributes to chemoresistance in triple‐negative breast cancers (TNBC), but the underlying mechanisms remain unclear. Here, the expression …
Source: Wiley Online LibraryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#BreastCancerAwarenessMonth 💕 De Zeng et al. | Inhibition of #Notch1 reverses EMT and chemoresistance to cisplatin via direct downregulation of #MCAM in #TripleNegativeBreastCancer cells Read it here - Free access! ➡️https://t.co/6MtOcJy8iY Part of IJC's #BCAM Virtual issue! https://t.co/YCVlQj4Ts3
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Read this week's Cancer Discovery #ResearchWatch: #NOTCH1 Mutations Inhibit Tumor Growth in the Esophageal Epithelium , summarizing the work of Emilie Abby, Phil Jones, et al. https://t.co/jkFNA1ZzFO @sangerinstitute https://t.co/y8cMf2VW79