This interactive tool demonstrates data from the Global Burden of Cardiovascular Diseases and Risks Collaboration, 1990-2021, which reports the magnitude of total CVD burden, including by disease state and risk factors across 21 global regions. This tool demonstrates the data in three sections: Total CVD mortality rates by region Mortality rates by CV disease state Risk factors, location metrics & socioeconomic data Explore each of these interactive settings to delve into these important global data. Published by the Global Burden of CVD Collaboration—an alliance between JACC, the Institute for Health Metrics and Evaluation, and the National Heart, Lung, and Blood Institute. J Am Coll Cardiol. 2022 Dec, 80 (25) 2372–2425.