• Mashup Score: 12

    People with neurofibromatosis type 1 (NF1) develop more types of cancer than previously recognized, according to a new study. They also developed some cancers at an earlier age and were more likely to die from several cancer types, compared with the general population. The findings emphasize the importance of preventive measures and early diagnosis for people with NF1.

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    • An inherited condition called neurofibromatosis type 1 (#NF1) is linked to the development of more types of cancer than previously realized. https://t.co/jdWzWJdUsE #repost #NFAwarenessDay

  • Mashup Score: 6

    Genetic analyses have become a critical part of many cancer diagnoses, and CCR scientists are seeking to expand the impact of this technology. They have teamed up with colleagues around the world to pore over DNA from patient samples, looking for patterns that reveal the presence of cancer or hint at the future behavior of a tumor. Their recent discoveries could lead to more personalized…

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    • A genetic study led by @khanjavnci and @jack_shern could lead to more personalized treatments for children with rhabdomyosarcoma and more reliable cancer screenings for children with #NF1. https://t.co/tQqV4woabQ @nci_ccr_pedonc #ICCD2023 #ChildhoodCancer https://t.co/GGvHGf09KB

  • Mashup Score: 3

    Objectives Variants in the neurofibromatosis type 1 (NF1) gene are not only responsible for the NF1 cancer predisposition syndrome, but also frequently identified in cancers arising in the general population. While germline variants are pathogenic, it is not known whether those that arise in cancer (somatic variants) are passenger or driver variants. To address this question, we sought to define…

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    • Study findings suggest a significant proportion of #NF1 variants in sporadic cancer may be passenger variants or hypomorphic alleles. Further mechanistic studies are warranted to define their unique roles in nonsyndromic cancer pathobiology. https://t.co/YUREHzLshc #NeuroTwitter https://t.co/xb0WQMe81J

  • Mashup Score: 5

    Objective To perform a longitudinal analysis of clinical features associated with neurofibromatosis type 1 (NF1) based on demographic and clinical characteristics and to apply a machine learning strategy to determine feasibility of developing exploratory predictive models of optic pathway glioma (OPG) and attention-deficit/hyperactivity disorder (ADHD) in a pediatric NF1 cohort. Methods Using…

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    • Predictive Modeling for Clinical Features Associated With #Neurofibromatosis Type 1: https://t.co/m3wekMNN4l #NeuroTwitter #NF1 https://t.co/wNJGqj8dxe

  • Mashup Score: 9

    Neurofibromatosis type 1 (NF1) is a genetic disorder that causes tumors to form on nerve tissue. NF1 is usually diagnosed in childhood, and there are no effective medical therapies for most types of tumors. Up to half of the people with NF1 develop plexiform neurofibromas (PNs). Over time, PNs may transform into atypical neurofibromas (ANFs) and then into cancerous tumors that grow along nerves….

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    • OPEN FOR ENROLLMENT: An NCI study is evaluating a potential treatment for neurofibromatosis type 1 and atypical neurofibromas in children. The study is evaluating a drug called abemaciclib. https://t.co/RL4CdGzT4X #CancerResearch #NF1 @NCIResearchCtr @NCI_CCR_PedOnc https://t.co/Pblfg5LaXl