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Mashup Score: 2Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function - 2 year(s) ago
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection of target cells requires the presence of furin, angiotensin-converting enzyme 2 (ACE2) receptors, and transmembrane protease serine 2 (TMPRSS2). Thus, cells in the body that express these proteins might be highly…
Source: www.nature.comCategories: Latest Headlines, UrologyTweet
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Mashup Score: 7Volume 18 Issue 11, November 2021 - 2 year(s) ago
Volume 18 Issue 11, November 2021
Source: www.nature.comCategories: Latest Headlines, UrologyTweet
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Mashup Score: 11Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry - Nature Reviews Urology - 3 year(s) ago
Biomarkers that can improve risk stratification of patients with prostate cancer are urgently needed. In this Review, Khoo et al. outline mass spectrometry technologies that enable the systematic discovery and targeted validation of protein-based biomarkers in prostate-associated fluids.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU Khoo et al. describe proteomic discovery of non-invasive biomarkers of localized #ProstateCancer using mass spec https://t.co/Qf2MFdCRKA @amandakhoo4 @lydialiu_yyl @dr_vesi @TheBoutrosLab @DrStanLiu @KislingerThomas @MBPatUofT @UHN_Research @PMResearch_UHN @Sunnybrook https://t.co/EmRM6UgnpX
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Mashup Score: 1The cognitive effect of anticholinergics for patients with overactive bladder - Nature Reviews Urology - 3 year(s) ago
Anticholinergics are a common class of medication used in the treatment of overactive bladder. However, concerns have been raised over the potential association of anticholinergics and cognitive impairment or dementia. This Review discusses the clinical evidence and provides guidance for prescribing anticholinergics in at-risk populations.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 0Prostate cancer screening: a new way forward or another false start? - Nature Reviews Urology - 3 year(s) ago
Serum PSA testing can identify men with clinically significant prostate cancer but exposes many more men to the diagnosis of indolent tumours. Benafif and colleagues have published the results of the BARCODE1 pilot study, in which they propose using germline single-nucleotide polymorphisms to identify men with a genetic risk of developing prostate cancer. Based on their preliminary findings,…
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 0On manels and manferences in urology - Nature Reviews Urology - 3 year(s) ago
Balancing diversity on panels at academic medical conferences demonstrates a commitment to the principles of diversity and inclusion. However, it seems we have a long way to go in urology, where two-thirds of sessions at major urology meetings still consist of all-male speaker panels.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 2Incorporating palliative care principles to improve patient care and quality of life in urologic oncology - Nature Reviews Urology - 3 year(s) ago
Society guidelines recommend incorporating palliative care into standard oncological care. However, misconceptions regarding palliative care are common — notably, palliative care and treatments seeking to cure or prolong life are not mutually exclusive. In this article, the authors discuss the integration of palliative care into surgical urologic oncology and consider palliative care guidelines,…
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 9Cellular senescence as a possible link between prostate diseases of the ageing male - Nature Reviews Urology - 3 year(s) ago
Senescent cells and their secretome — the senescence-associated secretory phenotype (SASP) — cause a systemic pro-inflammatory state, contributing to an inflammatory microenvironment. In this article, the authors discuss the presence of senescent cells and the SASP in the ageing prostate and the evidence for a role of senescence in BPH and prostate cancer, as well as possible therapeutic…
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 0Molecular events in neuroendocrine prostate cancer development - Nature Reviews Urology - 3 year(s) ago
Neuroendocrine prostate cancer predominantly develops from adenocarcinoma following a period of androgen suppressive treatment. Outcomes in patients with this disease are poor; the understanding of the molecular mechanisms behind its development will improve future targeted therapy options.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 0Combined advanced prostate cancer treatments: are they additive? - 3 year(s) ago
More than 50 clinical trials are currently exploring the combination of immunotherapy and other approved treatments for advanced prostate cancer. The results from a phase II trial of sipuleucel-T with or without radium-223 in patients with metastatic castration-resistant prostate cancer were recently published with intriguing findings.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
In a new Perspectives, @easley_lab and @rclaytoneden discuss mechanisms of a possible effect of SARS-CoV-2 in the testis and the potential implications for fertility https://t.co/2RcLghSazn #NewinNRU #Covid_19 #MensHealth https://t.co/sTz0tqRKZE