• Mashup Score: 6

    Why do cancer immunotherapies work so extraordinarily well in a minority of patients, but fail in so many others? By analyzing the role of neutrophils, immune cells whose presence usually signals treatment failure, scientists from the University of Geneva (UNIGE), from Harvard Medical School, and from Ludwig Cancer Center have discovered that there is not just one type of neutrophil, but several….

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    • Allies or enemies of #cancer: The dual fate of #neutrophils @UNIGEnews @CellCellPress https://t.co/hTM4JoMCHs

  • Mashup Score: 0

    Linde et al. describe a cancer therapy that activates neutrophils to infiltrate and eradicate tumors and reduce metastatic seeding. The authors elucidate the responsible mechanism, which involves complement component C5a, leukotriene B4, and reactive oxygen species, and demonstrate the potential of harnessing neutrophils through inflammatory activation to drive tumor clearance.

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    • SCI member Edgar Engleman and Postdoctoral scholar Ian Linde found when #neutrophils are activated they eliminate several types of tumors in laboratory mice. https://t.co/Z5ckngNSpo #ImmunoOncology https://t.co/b2Na5YkBJt

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    Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood. Design The impact of…

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    • Read the paper "Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis" via https://t.co/Z3jFPMXTFd #PancreaticCancer #Neutrophils #GUTImage https://t.co/e6cexGraYp

  • Mashup Score: 0

    Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood. Design The impact of…

    Tweet Tweets with this article
    • Read the paper "Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis" via https://t.co/Z3jFPMXTFd #PancreaticCancer #Neutrophils #GUTImage https://t.co/DJGuWQU80C