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Mashup Score: 5Unravelling the heart’s comic drama: can TLRs and hyaluronan metabolism stoke neutrophil rage in acute coronary syndrome? - 6 month(s) ago
This editorial refers to ‘Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study’, by D. Meteva et al., https
Source: academic.oup.comCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 7
BACKGROUND: Activation of immune-inflammatory pathways involving TNFα (tumor necrosis factor alpha) signaling is critical for revascularization and peripheral muscle tissue repair after ischemic inju
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis - 10 month(s) ago
Objective Interleukin (IL)-40 is a new cytokine related to immune system function and malignancies. Recently, an association of IL-40 with rheumatoid arthritis (RA) and externalisation of neutrophil extracellular traps (NETosis) was found. As neutrophils are implicated in RA development, we investigated IL-40 in early stages of RA (ERA). Methods IL-40 was determined in serum of treatment naïve…
Source: RMD OpenCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 6Allies or enemies of cancer: The dual fate of neutrophils - 1 year(s) ago
Why do cancer immunotherapies work so extraordinarily well in a minority of patients, but fail in so many others? By analyzing the role of neutrophils, immune cells whose presence usually signals treatment failure, scientists from the University of Geneva (UNIGE), from Harvard Medical School, and from Ludwig Cancer Center have discovered that there is not just one type of neutrophil, but several….
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 9Researchers identify neutrophils as major culprits in treatment resistance of pancreatic cancer - 1 year(s) ago
Researchers have shown for the first time exactly how immature neutrophils—white blood cells that are an important part of the immune system—are hijacked by pancreatic cancers to drive immunosuppression and treatment resistance. The study, led by investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, is published in Cancer Discovery, a journal…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2Extracellular CIRP Induces Novel Nectin-2+ (CD112+) Neutrophils to Promote Th1 Differentiation in Sepsis - 1 year(s) ago
Key Points. eCIRP induces CD112 (Nectin-2)-expressing neutrophils in sepsis via the TLR4 pathway.CD112+ neutrophils induce the Th1 phenotype when cocultured wit
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Neutrophil-activating therapy for the treatment of cancer - 1 year(s) ago
Linde et al. describe a cancer therapy that activates neutrophils to infiltrate and eradicate tumors and reduce metastatic seeding. The authors elucidate the responsible mechanism, which involves complement component C5a, leukotriene B4, and reactive oxygen species, and demonstrate the potential of harnessing neutrophils through inflammatory activation to drive tumor clearance.
Source: Cancer CellCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0ASSOCIATION BETWEEN BLOOD EOSINOPHILS AND NEUTROPHILS WITH CLINICAL FEATURES IN ADULT-ONSET ASTHMA - 1 year(s) ago
Asthma is a disease that can be separated into different phenotypes and endotypes based on the clinical characteristics and the molecular mechanisms of the condition, respectively.
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis - 1 year(s) ago
Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood. Design The impact of…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis - 1 year(s) ago
Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. Here, we investigate how the microenvironment in PDAC liver metastases reacts to chemotherapy and its role in metastatic disease progression post-treatment, an area which is poorly understood. Design The impact of…
Source: GutCategories: Gastroenterology, Latest HeadlinesTweet
Unravelling the heart’s comic drama: can TLRs and hyaluronan metabolism stoke neutrophil rage in acute coronary syndrome? https://t.co/FEfUR8nYhk #ACS #inflammation #TLR #hyaluronan #neutrophils #cardiotwitter @escardio @ESC_Journals https://t.co/QXI4OGsF1O