The prevalence of nonalcoholic fatty liver disease (NAFLD) in women of childbearing age in the United States has been estimated at 9%,1 but there are limited data on prevalence in pregnant people.2 Predominantly retrospective studies have suggested that NAFLD during pregnancy is associated with multiple adverse pregnancy complications, including gestational diabetes, preeclampsia, preterm birth, and postpartum hemorrhage.2–4 Prior studies have been limited primarily by reliance on diagnostic codes to identify women with NAFLD, potentially resulting in under-reporting and misclassification of NAFLD in pregnant women.

It is unclear whether health-related quality of life (HRQoL) is impaired in patients with nonalcoholic fatty liver disease (NAFLD) without advanced fibrosis and how this compares with the general population. We aimed to assess HRQoL in patients with NAFLD in comparison to the general population and any associations of fibrosis severity and metabolic comorbidities with impairments in HRQoL.