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Mashup Score: 11CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis - 5 hour(s) ago
Different from “7 + 3” combination, CPX-351 prevents mucosal damage, dysbiosis, and morbidity in intestinal inflammation.CPX-351 protects via the aryl hydr
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Mashup Score: 8Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia - 6 day(s) ago
Monosomy 7 and del(7q) result in a 1-copy deletion of the NAMPT gene at 7q22.3.NAMPT haploinsufficiency causes a vulnerability to the inhibition of NAMPT.
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Mashup Score: 51Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML - 7 day(s) ago
Mezigdomide potently degrades IKAROS, conferring broader activity in KMT2A-r and NPM1c AML models compared with lenalidomide and iberdomide.Mezigdomide syn
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Mashup Score: 69Making AML fly too close to the sun - 8 day(s) ago
Bourgeois and colleagues have identified that dual targeting of 2 transcriptional regulators, Ikaros and menin, is highly effective in distinct genetic sub
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Mashup Score: 6SETBP1 sets the stage - 15 day(s) ago
In this issue of Blood, Crespiatico et al1 explore the impact of the timing (founding event vs secondary acquisition) of SETBP1 mutation on the phenotype o
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Mashup Score: 40GPR56 in GVL: marker or mechanism? - 25 day(s) ago
In the current issue of Blood, Mathioudaki et al1 use single-cell RNA sequencing to identify adhesion G-protein coupled receptor GPR56 as a marker of an an
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Mashup Score: 25Validate User - 27 day(s) ago
We are sorry, but we are experiencing unusual traffic at this time. Please help us confirm that you are not a robot and we will take you to your
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Mashup Score: 59Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022 - 28 day(s) ago
When reclassifying 2130 oligomonocytosis cases using the WHO and ICC 2022 classifications, 356 and 241 cases are newly classified as CMML.Compared with MD-
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Mashup Score: 23Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis - 1 month(s) ago
KIT D816V confers resistance to TNF via BIRC5 (survivin) and promotes clonal dominance.High TNF levels are associated with inferior survival in SM.
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Mashup Score: 31Systemic mastocytosis: dying or survivin - 1 month(s) ago
In this issue of Blood, Greiner et al1 demonstrate that aberrant mast cells in systemic mastocytosis with the KIT D816V mutation release tumor necrosis factor (
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CPX-351 protects via the aryl hydrocarbon receptor–IL-22-IL-10 host pathway and the production of immunomodulatory metabolites by anaerobes. https://t.co/NXe107ls9S #myeloidneoplasia https://t.co/bAuwEkszzQ