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Mashup Score: 1Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma - Nature Communications - 9 month(s) ago
It is critical to understand what drives the progression of oesophageal adenocarcinoma (OAC) from a pre-cancerous state. Here, the authors use whole-genome sequencing to characterise the mutational processes and drivers of OAC progression from Barrett’s Oesophagus, as well as their prognostic associations.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 6Clonal diversification and histogenesis of malignant germ cell tumours - Nature Communications - 2 year(s) ago
The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
#Genomic and #transcriptomic analysis of #GermCellTumors of distinct histologies by @R_Rahbari et al. @sangerinstitute reveals somatic #evolution, clonal diversification, #MutationalSignatures and potential #biomarkers #CancerResearch @NatResCancer https://t.co/7Nt43Gzrp3 https://t.co/ukPwEFK5Sp
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Mashup Score: 20Mutational signatures are markers of drug sensitivity of cancer cells - Nature Communications - 2 year(s) ago
Mutational signatures can reveal the impact of mutagenic processes in cancer, including exposure to therapy. Here, the authors develop an approach that can accurately predict drug responses in cancer using mutational signatures while simultaneously correcting for germline variants with an ancestry matching procedure.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
The '#mutationalsignatures' of many genes hold the key to better #cancer therapies @UniBarcelona @NatureComms https://t.co/mAiIGvezqo https://t.co/NQRTQnMJdQ
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Mashup Score: 1Agenda – NCI Symposium on Mutation Signatures and Cancer - 2 year(s) ago
NCI SYMPOSIUM ON MUTATION SIGNATURES AND CANCER Opening Session 10:00 – 10:05Welcome and logisticsRon Johnson, Ph.D., Division of Cancer Biology, NCI 10:05 – 10:25Co-chair introduction Maria Teresa Landi, M.D., Ph.D.,…
Source: event.roseliassociates.comCategories: Genetics, Latest HeadlinesTweet-
Today December 3rd at 12:30PM ET: Dr. @prokuninaolsson, chief of #NCI_LTG, discusses #MutationalSignatures in translation at @theNCI #MutationSignatures21 symposium. https://t.co/odm6asGggM https://t.co/r4Lvy4HPVa
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Mashup Score: 25Mutational signatures: emerging concepts, caveats and clinical applications - Nature Reviews Cancer - 3 year(s) ago
Mutational signatures can provide insights into the origins and vulnerabilities of specific cancers, and have potential for clinical utility. This Review highlights recent developments in the field, providing insights into practical issues and challenges in mutational signature analysis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#NRCis20🎊 Featured in our anniversary issue: #MutationalSignatures: emerging concepts, caveats and clinical applications, by@GeneChChKoh, @_ADegasperi, @xueqing_zou, @SophieMomen & @SerenaNikZainal 🎉 https://t.co/C7hfxT2fEW @NatResCancer https://t.co/aKwFBg6ZBR
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Mashup Score: 14CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data - Nature Communications - 3 year(s) ago
Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with which they analyse the TCGA and PCAWG datasets.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
CloneSig: a tool for the joint estimation of intratumour #heterogeneity and #MutationalSignatures developed by @judithabk6 @jeanphi_vert @FabienReyal @institut_curie @MINES_ParisTech @GoogleAI #CancerResearch #CancerGenomics #bioinformatics @NatResCancer https://t.co/dLqDgWzZJX https://t.co/hk56Y5NIdR
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Mashup Score: 10Mutational signatures: emerging concepts, caveats and clinical applications - Nature Reviews Cancer - 3 year(s) ago
Mutational signatures can provide insights into the origins and vulnerabilities of specific cancers, and have potential for clinical utility. This Review highlights recent developments in the field, providing insights into practical issues and challenges in mutational signature analysis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NEW Review! @GeneChChKoh, @_ADegasperi, @xueqing_zou, @SophieMomen & @SerenaNikZainal discuss recent developments and challenges in the analysis of #MutationalSignatures to improve our understanding of origins and vulnerabilities of specific cancers. https://t.co/C7hfxT2fEW https://t.co/8Smub0zrYg
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Mashup Score: 3Learning mutational signatures and their multidimensional genomic properties with TensorSignatures - 3 year(s) ago
Currently available tools for the analysis of mutational signatures do not make use of all possible genomic properties aside from mutation patterns. Here the authors present TensorSignatures, an efficient framework that jointly infers mutational signatures and their genomic determinants.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet-
TensorSignatures: a multidimensional #tensor factorisation framework by @harald_voeh @moritzgerstung @avhoeck @ecuppen to infer #MutationalSignatures and their #genomic determinants #CancerResearch #bioinformatics #Genomics #MachineLearning @NatResCancer https://t.co/XWaAU2niRj https://t.co/bmU8VZgRzm
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Mashup Score: 4
Researchers at the Johns Hopkins Kimmel Cancer Center used machine learning techniques to detect mutational signatures in cancer patients. Their algorithm outperformed the current standard of analysis and revealed new mutational signatures associated with obesity, which is believed by cancer prevention experts to be becoming the most significant lifestyle factor contributing to cancer in the U.S….
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Researchers develop new method for identifying #mutationalsignatures in #cancer @elife https://t.co/8okwjgvkO5
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Mashup Score: 2The ways in which carcinogens work - 4 year(s) ago
Riva et al. exposed mice to a range of 20 known or suspected human carcinogens and then profiled the mutational signatures that arose in the tumours induced by them, finding that surprisingly the majority of the chemicals were not directly mutagenic.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New #ResearchHighlight! Riva et al. exposed mice to a range of #carcinogens & profiled the #mutationalsignatures that arose in the induced tumours - surprisingly the majority of the chemicals were not directly mutagenic. 🔥https://t.co/02dYML0dgK @NatResCancer @David_J_Adams https://t.co/1QC4dn01E0
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.@abbasshujath @RFitzgerald_lab @mariasecrier @EarlyCancerCam @UGI_at_UCL characterise the #mutationalsignatures and drivers of the progression from #BarrettsOesophagus to primary and metastatic #EsophagealAdenocarcinoma #CancerResearch @NatResCancer https://t.co/FM2oQ1wuDg