• Mashup Score: 0

    Gastrointestinal (GI) malignancies encompass a broad range of tumors with limited treatment options, particularly for advanced disease. With the development and implementation of next-generation sequencing (NGS) in routine practice, molecular-targeting therapies have been increasingly incorporated into the treatment paradigm for various cancers. Several drugs have achieved tissue-agnostic…

    Tweet Tweets with this article
    • 💥Hot off the press @CellPressNews @trendscancer Delighted to share our publication👉Impact of tissue-agnostic approvals for patients with gastrointestinal malignancies 🧬🎯#PrecisionMedicine #BRAF #RET #MSI #Her2 #NRG #FGFR @curecc @OncoAlert https://t.co/rcFhkNwL0z https://t.co/jJlQ848pTx

  • Mashup Score: 1

    A 43-year-old woman presented with recurrent metastatic colon cancer with metastases to the peritoneum after having initially been diagnosed with stage IIB colon cancer and deferring adjuvant chemotherapy. Circulating tumor DNA (ctDNA)-based liquid biopsy testing revealed microsatellite instability-high (MSI-H) status, which was also confirmed on tissue testing. This patient then underwent four…

    Tweet Tweets with this article
    • 🤔What if the tumor is #MSI-High & has a #TRK-FUSION🛻 🧬❓ 🆕Published today🗞👇🏾 #ColorectalCancer❌response to #Immunotherapy (Pembro & IPI➕NIVO) ➡️brisk & CURATIVE response to NTRK⛔️Larotrectinib. #ctDNA #CRCSM #PrecisionMedicine @OncoAlert Link: https://t.co/wr6wyAFa0K https://t.co/4QpDyv1I2z

  • Mashup Score: 12

    KRAS-WT PDAC represents 10.7% of PDAC and is enriched with targetable alterations, including immuno-oncologic markers. Identification of KRAS-WT patients in clinical practice may expand therapeutic options in a clinically meaningful manner.

    Tweet Tweets with this article
    • Just out! @CCR_AACR multi-inst collab @carisls POA #pancsm clinically relevant #KRAS WT subset w/mol targets #PDAC #braf #fgfr2 #alk #ret #ntrk1 #nrg1 #erbb2 #msi #tmb @DrHendifar @paphilip @OncoAlert @m_khushman @marshalj23 @doctormikehall https://t.co/Xrt5oZz1Ak @CSCancerCare https://t.co/p6HGA9hshI

  • Mashup Score: 1

    Two major molecular pathways of colorectal carcinogenesis, chromosomal instability (CIN) and microsatellite instability (MSI), are considered to be mutually exclusive. Distinguishing CIN from MSI-high tumors has considerable therapeutic implications, because patients with MSI-high tumors can derive considerable benefit from immune checkpoint inhibitors, and tumors that evolved through the CIN…

    Tweet Tweets with this article
    • FAP #colorectalcancer develops via CIN and #LynchSyndrome crcs develop via #MSI. So I always thought that FAP-related colorectal cancers would never be MSI-H. Until this case: https://t.co/7wy9DAYiuw Thanks to the pt for letting us publish her story @JNCCN @sm_blum

  • Mashup Score: 3

    PURPOSE Next-generation sequencing (NGS) testing is being incorporated into routine standard of care for patients with cancer. Immune checkpoint inhibitors (CPIs) are approved for use in both tumor-specific and tumor-agnostic indications. We sought to determine tumor type–specific or tumor-agnostic correlations between mutations detected by NGS and response to CPIs. MATERIALS AND METHODS A…

    Tweet Tweets with this article
    • #NGS-based analysis of 26,004 patients treated with #immunotherapy: 1. high #TMB and #MSI combined better outcome, means they identify different patients; 2. specific genomic alterations predictive of resistance despite hTMB and MSI-H indicated @OncoAlert https://t.co/Wr88kCkgs7 https://t.co/r4Ty6zUcnT