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    Wolters Kluwer Health - 10 month(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

    Source: lww.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      OncologyTimes

      Personalized mRNA vaccine combined with immunotherapy reduces the risk of death or recurrence by 44% in high-risk melanoma patients. This is a promising step towards tailored cancer treatments. #mRNAVaccine #Immunotherapy https://t.co/2n9qCgxXnH https://t.co/jkRB5mOSO8

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    A Vaccine for Pancreatic Cancer Treatment? - 12 month(s) ago

    I have to say, this new paper is good news on the oncology front. It’s from researchers at Sloan-Kettering and BioNTech (among others) and presents the results of a small trial treating patients with pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). This is another crack at the “personalized cancer therapy” idea and simultaneously at the “cancer vaccine” idea, and it’s fair…

    Source: www.science.org
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      Nice summary of "effect size" in #mRNAvaccines for #PancreaticCancer in @ScienceMagazine 👇🏽 https://t.co/8y74mxRNEQ But: 50% no response = ❓as non-responders enriched (not ss) in pts with no spleen. Spleen ⬆️ IV #mRNAvaccine response (👉🏽🧵 https://t.co/8ndGZADgDH )

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    GitHub - zsethna/CloneTrack - 12 month(s) ago

    Contribute to zsethna/CloneTrack development by creating an account on GitHub.

    Source: GitHub
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      21. Sidebar – we think #CloneTrack can track any #vaccine expanded clones, so if interested 👉🏽https://t.co/FhMl1EJ8uy We found… #mRNAvaccine expanded T cells are - CD8’s (see paper; re: CD4’s > see discussion). - High magnitude (👇🏽can reach upto 10% of all blood T cells….!) https://t.co/e7UgmzL84X

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    Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer - Nature - 12 month(s) ago

    A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      27. Can #mRNAvaccine expanded T cells detect micrometastases? Interesting clinical vignette in Figure 4 👉🏽 here https://t.co/d1SgGgdVHq.

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      TheVinodLab

      9. So, in 2017, we partnered with Ira Mellman @Genentech + Ugur Sahin @BioNTech_Group, to answer: Are #mRNAvaccinesagainst NAs in #PDAC 1) Feasible (despite #PDACs have few NAs)? 2) Safe? 3) Able to activate T cells? Now answers in @nature https://t.co/d1SgGgdVHq.

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    Flu Virus-Inspired Nanoparticles for mRNA Delivery | Medgadget - 2 year(s) ago

    Researchers at the University of California San Diego developed a new delivery technique for mRNA. The method involves flu virus-inspired nanoparticles that can escape endosomes, the acidic vesicles that engulf and destroy materials that attempt to enter cells. The nanoparticles contain a protein receptor that allows them to unlock the endosomes and release the mRNA into the interior of…

    Source: www.medgadget.com
    Categories: Future of Medicine, Latest Headlines
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      Medgadget

      #Flu Virus-Inspired Nanoparticles for mRNA Delivery https://t.co/tClji3Us4A #MRNAVaccine #UCSD #Genetics #Medicine #Nanomedicine #PublicHealth https://t.co/bDUSsVdffV

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    Symptoms after first mRNA vaccine dose linked to previous SARS-CoV-2 infection - 3 year(s) ago

    Previous SARS-CoV-2 exposure increased the odds of developing clinically significant symptoms following the first dose of a COVID-19 mRNA vaccine, researchers reported in JAMA Internal Medicine. “These vaccines can elicit greater local and systemic reactions in persons with prior SARS-CoV-2 infection,” Amanda K. Debes, PhD, MS, an assistant scientist in the department of international

    Source: www.healio.com
    Categories: General Medicine News, Latest Headlines
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      GoHealio

      Previous #SARSCoV2 exposure increased the odds of developing clinically significant symptoms following the first dose of a #COVID19 #mRNAvaccine, researchers from @JohnsHopkinsSPH reported in the issue of @JAMAInternalMed that came out today https://t.co/qf6UPr6HwV

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