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Mashup Score: 6
cruited to their target genes by the mixed lineage leukemia (MLL) complex, which involves a direct interaction between MLL and Menin. Here, we show that therapeutic targeting of the Menin–MLL interaction inhibits the propagation of NUP98-rearrranged AML both ex vivo and in vivo. Treatment of primary AML cells with the Menin inhibitor revumenib (SNDX-5613) impairs proliferation and clonogenicity ex vivo in long-term coculture and drives myeloid differentiation. These phenotypic effects are associated with global gene expression changes in primary AML samples that involve the downregulation of many critical NUP98 fusion protein-target genes, such as MEIS1 and CDK6. In addition, Menin inhibition reduces the expression of both wild-type FLT3 and mutated FLT3-ITD, and in combination with FLT3 inhibitor, suppresses patient-derived NUP98-r AML cells in a synergistic manner. Revumenib treatment blocks leukemic engraftment and prevents leukemia-associated death of immunodeficient mice transplan
Source: journals.lww.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3Morel-Lavallee Lesions - Diagnosis and practical management of these troublesome injuries! - BJSM blog - social media's leading SEM voice - 2 year(s) ago
Part 2 – Management & Infographic Management Many factors need to be taken into account when determining the approach to managing a Moral-Lavallee lesion. Different management forms include conservative treatment, minimally invasive treatment, and surgical intervention. Conservative approach Lesions with small fluid collections and no overlying pressure changes may be managed by conservative…
Categories: Latest Headlines, RheumatologyTweet-
⚠️ Morel-Lavallee Lesions - part 2 of this #BJSMBlog series ✅ How should #MLL be managed? Find out more ⬇️ #Infographic https://t.co/SUOYdgzz8T https://t.co/QSdK8K6Fr6
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Mashup Score: 1Morel-Lavallee Lesions - Diagnosis and practical management of these troublesome injuries! - BJSM blog - social media's leading SEM voice - 2 year(s) ago
Part 2 – Management & Infographic Management Many factors need to be taken into account when determining the approach to managing a Moral-Lavallee lesion. Different management forms include conservative treatment, minimally invasive treatment, and surgical intervention. Conservative approach Lesions with small fluid collections and no overlying pressure changes may be managed by conservative…
Categories: Latest Headlines, RheumatologyTweet-
Did you miss this #BJSMBlog ⁉️ ⚠️ Morel-Lavallee Lesions - part 2 of this blog series ✅ How should #MLL be managed? Find out more ⬇️ #Infographic https://t.co/SUOYdgzz8T https://t.co/VwdsEwftLN
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Mashup Score: 1Morel-Lavallee Lesions - Diagnosis and practical management of these troublesome injuries! - BJSM blog - social media's leading SEM voice - 2 year(s) ago
Part 2 – Management & Infographic Management Many factors need to be taken into account when determining the approach to managing a Moral-Lavallee lesion. Different management forms include conservative treatment, minimally invasive treatment, and surgical intervention. Conservative approach Lesions with small fluid collections and no overlying pressure changes may be managed by conservative…
Categories: Latest Headlines, RheumatologyTweet-
⚠️ Morel-Lavallee Lesions - part 2 of this #BJSMBlog series ✅ How should #MLL be managed? Find out more ⬇️ #Infographic https://t.co/SUOYdgzz8T https://t.co/8y6hkFfl7W
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RT @Wang_Yu_Hung: The #MLL–#Menin Interaction is a Therapeutic Vulnerability in #NUP98-rearranged #AML https://t.co/1OuRUE7ns2 #FLT3 #leus…