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Mashup Score: 11Long-Term Safety Outcomes of Fecal Microbiota Transplantation: Real-World Data Over 8 Years From the Hong Kong FMT Registry - 1 month(s) ago
Prospective long-term real-world safety data after fecal microbiota transplantation (FMT) remain limited. We reported long-term outcomes of FMT from a population-based FMT registry in Hong Kong.
Source: www.cghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 4A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut - 6 month(s) ago
Objective Ample evidence exists for the role of abnormal gut microbiota composition and increased gut permeability (‘leaky gut’) in chronic inflammation that commonly co-occurs in the gut in both obesity and diabetes, yet the detailed mechanisms involved in this process have remained elusive. Design In this study, we substantiate the causal role of the gut microbiota by use of faecal conditioned media along with faecal microbiota transplantation. Using untargeted and comprehensive approaches, we discovered the mechanism by which the obese microbiota instigates gut permeability, inflammation and abnormalities in glucose metabolism. Results We demonstrated that the reduced capacity of the microbiota from both obese mice and humans to metabolise ethanolamine results in ethanolamine accumulation in the gut, accounting for induction of intestinal permeability. Elevated ethanolamine increased the expression of microRNA- miR-101a-3p by enhancing ARID3a binding on the miR promoter. Increased m
Source: gut.bmj.comCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the paper by Mishra et al entitled "A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut" via https://t.co/kuEBftGE9K #Microbiota #Obesity https://t.co/hO91K6InFl
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Mashup Score: 4An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism - 6 month(s) ago
Shelton et al. determine that early-life antibiotics exacerbate diet-induced obesity by disrupting interactions between the gut microbiota and the small intestine epithelium. Their study identifies that a Lactobacillus-derived metabolite, phenyllactic acid, regulates intestinal PPAR-γ to limit fat accumulation, revealing a mechanism by which the early-life microbiota protects against metabolic dysfunction.
Source: www.cell.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism: Cell Host & Microbe #microbiota #microbiome #obesity https://t.co/4KQOazd7RX
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Mashup Score: 0Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma - 7 month(s) ago
Analysis of intratumoral microbiota in patients with esophageal cancer identifies a microbiota signature that is associated with chemoimmunotherapy response and reveals that Streptococcus induces a favorable response by stimulating CD8+ T-cell infiltration.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the September 15 issue— Intratumoral #Microbiota Composition Regulates #Chemoimmunotherapy Response in Esophageal Squamous Cell #Carcinoma, by Wu et al. https://t.co/4Rc526xu0S https://t.co/RJmAWJZf58
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Mashup Score: 2The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease - 7 month(s) ago
Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors. Objective To develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices. Design An international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on
Source: gut.bmj.comCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the #GUTGuideline by @LRLopetuso @DeleuSara et al on "The first international Rome consensus conference on gut #microbiota and #FMT in #IBD" via https://t.co/7seMU3z08F @LGodny @h_sokol @gianluca1aniro @ibddocmaria @Iris_Dotan @alearmuzzi @GiovanniCammar9 https://t.co/xyBRuK6V1P
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Mashup Score: 6The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease - 8 month(s) ago
Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors. Objective To develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices. Design An international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on
Source: gut.bmj.comCategories: Gastroenterology, Latest HeadlinesTweet-
#GUTImage from the #GUTGuideline by @LRLopetuso @DeleuSara et al on "The first international Rome consensus conference on gut #microbiota and #FMT in #IBD" via https://t.co/7seMU3z08F @LGodny @h_sokol @gianluca1aniro @ibddocmaria @Iris_Dotan @alearmuzzi @GiovanniCammar9 https://t.co/8tMMWWFFXS
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Mashup Score: 2Microbiota and Depressive Disorders: Prof. Antonio Giordano| SHRO - 8 month(s) ago
There is a correlation between the intestinal microbiota and the onset of mood and memory disorders, and it is determined by the ability of the microbiota to regulate the production of neurotransmitters such as dopamine, serotonin, and norepinephrine. Inflammation of the intestinal tract, which causes the release of pro-inflammatory cytokines like TNF-alpha, IL-6, and MCP, able to pass the blood-brain barrier and affect an individual’s health and mind, is in fact one of the most reliable biologi
Source: www.drantoniogiordano.comCategories: Hem/Oncs, Latest HeadlinesTweet-
#Blogpost: "The Role of Microbiota in Depressive Disorders" The gut microbiota significantly impacts mood and memory disorders by regulating neurotransmitter production, including dopamine, serotonin, and norepinephrine. Click here: https://t.co/qGERY1OY5m #microbiota #health… https://t.co/N3rCfL7HmH
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Mashup Score: 9A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection - 8 month(s) ago
Nature Biotechnology – Resident microbiota contribute to HIV and EBV infection in a germ-free humanized mouse model.
Source: www.nature.comCategories: Infectious Disease, Latest HeadlinesTweet-
Researchers at @UNC with Dr. Victor Garcia developed a 🦠 germ-free humanized mouse model that shows the contribution of resident #microbiota to two human-specific #pathogen infections, Epstein–Barr virus and #HIV! 📖 @NatureBiotech | https://t.co/Umr7OKx2JI https://t.co/tq9khwu9Lg
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Mashup Score: 8Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes - 9 month(s) ago
Gut microbiota influence host immunity and metabolism during obesity. Bacterial sensors of the innate immune system relay signals from specific bacter…
Source: www.sciencedirect.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @ojcius: #microbiota and Nod-like receptors balance #inflammation and #metabolism during #obesity and #diabetes https://t.co/iD0GcWtQnC…
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Mashup Score: 0Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review - 9 month(s) ago
Vanessa C Harris and colleagues review the currently available literature to report how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and, the implications for antimicrobial resistant infections.
Source: journals.plos.orgCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and report implications for antimicrobial resistant infections: https://t.co/zBlglW5D49… @CB_Luchen @bwantu @aighd #AMR #microbiota https://t.co/VYva4ChKKc
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Prospective real-world data from Asia’s first fecal #microbiota transplantation registry demonstrated that FMT has an excellent long-term safety profile. Click the link to learn more 🔗 https://t.co/SVrunSy3Z6 https://t.co/sGwBJYErSn