-
Mashup Score: 0Characterization of low‐grade epilepsy associated tumor from implanted stereoelectroencephalography electrodes - 6 month(s) ago
Low-grade epilepsy associated tumors (LEATs) are a common cause of drug-resistant epilepsy in children. Herein we demonstrate the feasibility of using tumor tissue derived from stereoelectroencephalo…
Source: onlinelibrary.wiley.comCategories: Latest Headlines, NeurologyTweet
-
Mashup Score: 0
Background Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may improve both the adherence to screening and the selection to colonoscopy. In this study, we conducted a serum-based discovery and validation of cfDNA methylation biomarkers for CRC screening in a multicenter cohort of 433 serum samples including healthy controls, benign pathologies, advanced adenomas (AA), and CRC. Results First, we performed an epigenome-wide methylation analysis with the MethylationEPIC array using a sample pooling approach, followed by a robust prioritization of candidate biomarkers for the detection of advanced neoplasia (AN: AA and CRC). Then, candidate biomarkers were validated by pyrosequencing in independent individual cfDNA samples. We report GALNT9, UPF3A, WARS, and LDB2 as new noninvasive biomarkers for the early detection o
Categories: Future of Medicine, Latest HeadlinesTweet-
Glad to have participated in #colorectal #cancer #CRC screening study using DNA #methylation biomarkers in cell-free DNA #cfDNA of more than 400 samples; article published in Clinical Epigenetics @BioMedCentral led by Loretta De Chiara @cinbio_uvigo @uvigo https://t.co/CqBTwWmd6w https://t.co/NY9gyydutH
-
-
Mashup Score: 0Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer - 8 month(s) ago
DNA hypermethylation at the GSTP1 promoter progressively spreads from being unmethylated in normal prostate to intermediate levels in precursor lesions to extensive methylation in cancer. This molecular progression of GSTP1 promoter methylation patterns in early prostate carcinogenesis could be useful for identification and interception of prostate cancer precursors.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
DNA hypermethylation of the GSTP1 promoter increases from unmethylated (normal prostate) to intermediate levels (precursor lesions) to extensive (#ProstateCancer). #Methylation patterns could be useful for early detection and interception. https://t.co/GbNzdwPTBl @KimmelCancerCtr https://t.co/d1lzEaCFjl
-
-
Mashup Score: 3Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function - 8 month(s) ago
Inflammatory signals are key in development and cell differentiation but their orchestration with pluripotency and stemness signals is poorly understood. Our previous work identified a chromatin function of IκBα, the NF-κB inhibitor, that is crucial for differentiation in different types of somatic stem cells. Here we demonstrate that deficiency of IκBα imposes a profound chromatin rewiring defect that impacts on DNA methylation, histone post-translational modifications and transcriptional regulation, stabilizing mouse embryonic stem cells (ESCs) in a ground state of pluripotency while preventing them from pluripotency exit and differentiation. By engineering separation-of-function mutants of IκBα with specific binding to either NF-κB or histones, we demonstrate that regulation of pluripotency state by IκBα is independent of NF-κB but requires the chromatin-related IκBα function. ### Competing Interest Statement patent on IkBa SOF mutants
Source: www.biorxiv.orgCategories: Future of Medicine, Latest HeadlinesTweet-
Glad to help in @biorxivpreprint article by @BigSpinLab @CarrerasIJC @hospitaldelmar about how IκBα defect induces #chromatin rewiring by DNA #methylation and #histone modifications, preventing #embryonic stem cells #pluripotency exit and #differentiation https://t.co/nWRfVdbk04 https://t.co/vbTWZhCzaV
-
-
Mashup Score: 0Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer - 9 month(s) ago
DNA hypermethylation at the GSTP1 promoter progressively spreads from being unmethylated in normal prostate to intermediate levels in precursor lesions to extensive methylation in cancer. This molecular progression of GSTP1 promoter methylation patterns in early prostate carcinogenesis could be useful for identification and interception of prostate cancer precursors.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
DNA hypermethylation of the GSTP1 promoter increases from unmethylated (normal prostate) to intermediate levels (precursor lesions) to extensive (#ProstateCancer). #Methylation patterns could be useful for early detection and interception. https://t.co/V2XNilQB6a @KimmelCancerCtr https://t.co/SFhePql6j6
-
-
Mashup Score: 0Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome - Leukemia - 9 month(s) ago
Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity and therapeutic outcome. In this study, we investigated culture-associated epigenetic changes in CAR T cells and found continuous gain of DNAm, particularly within genes…
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
Discovery with clinical implications, we just reported in @LeukemiaJnl that culture conditions modify DNA #methylation of Chimeric Antigen Receptor CAR-T cells affecting efficacy of #immunotherapy, research led by Wolfgang Wagner @lab_wagner @RWTH https://t.co/jKeuN3cwb9 https://t.co/WIURXOxpE5
-
-
Mashup Score: 0More Green Spaces Linked to Slower Biological Aging - News Center - 10 month(s) ago
Living near to green spaces were associated with slower biological aging, according to a Northwestern Medicine study published in Science Advances.
Source: News CenterCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
“Our study highlights that the natural environment affects your health at a molecular level (changes in DNA #methylation),” said Lifang Hou, MD, PhD, director of our Center for Global Oncology @NUFeinbergMed: https://t.co/DUmi7QHJ08 #epigenetics
-
-
Mashup Score: 2Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics - Cancer and Metastasis Reviews - 10 month(s) ago
Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA modifiers, namely writers, readers, and erasers; enzymes responsible of respectively introducing,…
Source: SpringerLinkCategories: Future of Medicine, Latest HeadlinesTweet-
Online our article "Cancer metastasis under the magnifying glass of #epigenetics and #epitranscriptomics" in Cancer and #Metastasis Reviews @SpringerNature describing how DNA #methylation, and histone and RNA modifications contribute to dissemination https://t.co/AAH2PHZRpY https://t.co/1A814wOGeI
-
-
Mashup Score: 0
Background RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. Methods Combining data mining and conventional experimental procedures, NSUN7 methylation and expression status was assessed in liver cancer cell lines and primary tumors. Loss-of-function…
Source: BioMed CentralCategories: Future of Medicine, Latest HeadlinesTweet-
Grateful to Vanessa Ortiz-Barahona's work and help JM LLovet @IcahnMountSinai @idibaps @hospitalclinic and Thomas Preiss @JCSMR @tominaustralia @VictorChangInst, #livercancer and #5mC #RNA experts, to show #NSUN7 #DNA #methylation loss in #hepatic tumors https://t.co/8ZFs6IF82W https://t.co/RHLxyaoCiq
-
-
Mashup Score: 0
Key Points. MSRE-qPCR is an accurate and rapid method to determine TSDR methylation status.MSRE-qPCR produces similar results to previously described orthogonal
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI from Christopher M. Borges @editasmed Method to assess #methylation status and purity of #Treg cells from ex vivo primary human Treg culture #ReadTheJI #immunologicalmethods 👉 https://t.co/l6VyYPdyhv https://t.co/5dSaykLsWg
-
Short research! https://t.co/0T7JFtMInZ #LEATs #sEEG #mutation #methylation #epilepsy #ILAE #openaccess @IlaeWeb @epilepsiaopen @WileyNeuro https://t.co/OLStM0vUIM