-
Mashup Score: 0
Metastases to the thyroid gland can present a diagnostic challenge with respect to the cytological and histological evaluation of thyroid lesions. Data from the literature indicates that the rate of metastases to the thyroid gland ranges between 0% and 24% for patients with thyroid nodules in autopsy series, but according to clinical series the reported incidence varies between 0·1% and 3%.1–5 This discrepancy shows that metastatic thyroid lesions are frequently missed or misdiagnosed in their clinical evaluation.
Source: www.thelancet.comCategories: Endocrinology, Latest HeadlinesTweet
-
Mashup Score: 1TMEM215 Prevents Endothelial Cell Apoptosis in Vessel Regression by Blunting BIK-Regulated ER-to-Mitochondrial Ca Influx - 6 month(s) ago
BACKGROUND: In developmental and pathological tissues, nascent vessel networks generated by angiogenesis require further pruning/regression to delete nonfunctional endothelial cells (ECs) by apoptosi
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
First time author @CircRes Zhang & colleagues found that disruption of #Tmeme215, an #ER membrane protein, in #ECs represses tumor growth and lung #metastasis. Learn more at https://t.co/lcIb0v9iLk https://t.co/nqmEqKaitc
-
-
Mashup Score: 2Apply - Interfolio - 6 month(s) ago
The Center for Metastasis Research eXcellence (MET-X) at the Fred Hutchinson Cancer Center (Fred Hutch) is launching an open-rank faculty search for a laboratory-based scientist to lead a research program focused on uncovering fundamental mechanisms of cancer metastasis. The successful candidate will enter a dynamic research environment that encourages taking bold risks, has forums and financial…
Source: apply.interfolio.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Want to apply your knowledge of spatial transcriptomics, high throughput functional genomics, mass-spec based imaging, and/or intravital imaging to studying the fundamental mechanisms of #metastasis? @FredHutch_Met_X is #hiring! Learn more and apply: https://t.co/FmdE8YP2XE https://t.co/MhU2GeGr8u
-
-
Mashup Score: 0Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 6 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/iBqDFBU2KY @WeizmannScience @TelAvivUni #Metastasis https://t.co/JY1wVUdAyD
-
-
Mashup Score: 3Apply - Interfolio - 6 month(s) ago
The Center for Metastasis Research eXcellence (MET-X) at the Fred Hutchinson Cancer Center (Fred Hutch) is launching an open-rank faculty search for a laboratory-based scientist to lead a research program focused on uncovering fundamental mechanisms of cancer metastasis. The successful candidate will enter a dynamic research environment that encourages taking bold risks, has forums and financial…
Source: apply.interfolio.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Want to apply your knowledge of spatial transcriptomics, high throughput functional genomics, mass-spec based imaging, and/or intravital imaging to studying the fundamental mechanisms of #metastasis? @FredHutch_Met_X is #hiring! Learn more and apply: https://t.co/FmdE8YP2XE https://t.co/egQB7vmTzy
-
-
Mashup Score: 2Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment - 7 month(s) ago
Galectin-1 increases STING stability in cancer cells that activates NF-κB signaling and CXCL2 expression to promote MDSC trafficking, which stimulates the generation of a pre-metastatic niche and facilitates metastatic progression.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read the article in the latest issue— Galectin-1 Mediates Chronic STING Activation in Tumors to Promote #Metastasis through MDSC Recruitment, by @dnambiar_86, @Qle_stanford et al. https://t.co/bvcKNxR2Ou @StanfordMed https://t.co/PI2LBxcKMU
-
-
Mashup Score: 1Cancer Research - 7 month(s) ago
Read the current issue of Cancer Research.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Attending #AACRpan23? Check out our latest issue, which includes #pancreaticcancer research that provides mechanistic insights into gemcitabine resistance and #KRAS-driven #metastasis and identifies synergistic effects of combining ERBB & KRAS inhibitors. https://t.co/3DKDwzR6cL https://t.co/rwoWdVUUoM
-
-
Mashup Score: 8Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 7 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/YlACKewCgv @WeizmannScience @TelAvivUni #Metastasis https://t.co/ovY4dimzeG
-
-
Mashup Score: 1Cancer Research - 7 month(s) ago
Read the current issue of Cancer Research.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Attending #AACRpan23? Check out our latest issue, which includes #pancreaticcancer research that provides mechanistic insights into gemcitabine resistance & #KRAS-driven #metastasis & identifies synergistic effects of combining ERBB & KRAS inhibitors. https://t.co/bdmymHI7XH https://t.co/Txcj7aRxb2
-
-
Mashup Score: 3p53 gain-of-function mutation induces metastasis via Brd4-dependent Csf-1 expression - 7 month(s) ago
Abstract. TP53 mutations are frequent in esophageal squamous cell carcinoma (ESCC) and other SCCs, and are associated with a proclivity for metastasis. Here, we report that Colony-stimulating factor-1 (Csf-1) expression is upregulated significantly in a p53-R172H-dependent manner in metastatic lung lesions of ESCC. The p53-R172H-dependent Csf-1 signaling through its cognate receptor Csf-1r increases tumor cell invasion and lung metastasis, which in turn is mediated in part through Stat3 phosphorylation and epithelial-to-mesenchymal transition. In Trp53R172H tumor cells, p53 occupies the Csf-1 promoter. The Csf-1 locus is enriched with histone 3 lysine 27 acetylation (H3K27ac), which likely is permissive for fostering an interaction between Brd4 and p53-R172H to regulate Csf-1 transcription. Inhibition of Brd4 not only reduces tumor invasion and lung metastasis, but also reduces circulating Csf-1 levels. Overall, our results establish a novel p53-R172H-dependent Brd4-Csf-1 axis that pro
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
OnlineFirst: #p53 Gain-of-Function Mutation Induces #Metastasis via BRD4-dependent Csf-1 expression, by Gizem Efe, @ARustgi et al. https://t.co/MLf0N6Ml0E @columbiacancer https://t.co/p1zdbgkipa
-
When the #cytological evaluation of a #thyroid #lesion does not match all the usual criteria for a primary thyroid lesion, the possibility of a #metastasis to the thyroid gland should be kept in mind https://t.co/x2lkZ6uv20 #metastases