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    Background Homozygous familial hypercholesterolemia (HoFH) is an orphan metabolic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C), xanthomas, aortic stenosis, and premature atherosclerotic cardiovascular disease (ASCVD). In addition to LDL-C, studies in experimental models and small clinical populations have suggested that other types of metabolic molecules might also be risk factors responsible for cardiovascular complications in HoFH, but definitive evidence from large-scale human studies is still lacking. Herein, we aimed to comprehensively characterize the metabolic features and risk factors of human HoFH by using metabolic systems strategies. Methods Two independent multi-center cohorts with a total of 868 individuals were included in the cross-sectional study. First, comprehensive serum metabolome/lipidome-wide analyses were employed to identify the metabolomic patterns for differentiating HoFH patients (n = 184) from heterozygous FH (HeFH,

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    • #Metabolomic study from Zhiyong Du et al. update molecular insights of clinical phenotypes and #cardiovascular risk in patients with homozygous familial #hypercholesterolemia #HoFH More and complexer metabolic abnormalities than previously known: https://t.co/tWJnx77o3Z https://t.co/QI2GthX6sG

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    Dr. Suneel Kamath from the Cleveland Clinic – Young onset colorectal cancer (yoCRC) has been increasing over the past few decades, and the reasons behind this rise are still not well understood. Dr. Suneel Kamath and his team conducted a study using metabolomics to gain insights into the underlying factors contribut…

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    • 📣 ASCO 2023 🧪🔬 Dr. @SKamath_MD, from @CleClinicMD, discusses the #ASCO23 abstract that is unraveling the #metabolomic differences between young-onset and average-onset #colorectal #adenocarcinoma (CRC). 🎯🩺 🔗 https://t.co/sb6h7w8d1F https://t.co/1vXZcgIgPy

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    AbstractAims. Cardiac energetic impairment is a major finding in takotsubo patients. We investigate specific metabolic adaptations to direct future therapies.Me

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    • Are energy deficits the cause of a “broken” #heart? New study finds #Takotsubo syndrome is associated with #metabolomic dysregulation in glycolytic and beta-oxidation pathways https://t.co/kFig9q0xHq @CVR_TomaszGuzik @DrMikeDrozd #thinkPET #HeartFailure #CardiovascularResearch https://t.co/d43XR6ayAy