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Mashup Score: 1
Background Homozygous familial hypercholesterolemia (HoFH) is an orphan metabolic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C), xanthomas, aortic stenosis, and premature atherosclerotic cardiovascular disease (ASCVD). In addition to LDL-C, studies in experimental models and small clinical populations have suggested that other types of metabolic molecules might also be risk factors responsible for cardiovascular complications in HoFH, but definitive evidence from large-scale human studies is still lacking. Herein, we aimed to comprehensively characterize the metabolic features and risk factors of human HoFH by using metabolic systems strategies. Methods Two independent multi-center cohorts with a total of 868 individuals were included in the cross-sectional study. First, comprehensive serum metabolome/lipidome-wide analyses were employed to identify the metabolomic patterns for differentiating HoFH patients (n = 184) from heterozygous FH (HeFH,
Source: bmcmedicine.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0
Dr. Suneel Kamath from the Cleveland Clinic – Young onset colorectal cancer (yoCRC) has been increasing over the past few decades, and the reasons behind this rise are still not well understood. Dr. Suneel Kamath and his team conducted a study using metabolomics to gain insights into the underlying factors contribut…
Source: oncologytube.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach - BMC Medicine - 1 year(s) ago
Background Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking. Therefore, this study aimed to investigate distinctive metabolites during the preconception phase between GDM and non-GDM controls in a nested case–control study in Singapore. Methods Within a…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients - 1 year(s) ago
ME/CFS is an understudied multisystemic disease. Xiong et al. present an integrated multi-‘omics analysis comparing ME/CFS patients with matched controls. Short-term disease was characterized by greater gut microbial dysbiosis, particularly a depletion of butyrate-producing microbes; long-term disease was associated with more severe phenotypic and metabolic abnormalities.
Source: Cell Host & MicrobeCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0
Background: Racial differences in metabolomic profiles may reflect underlying differences in social determinants of health by self-reported race and may be related to racial disparities in coronary h
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Metabolomic Biomarkers to Predict and Diagnose Cystic Fibrosis Pulmonary Exacerbations: A Systematic Review - PubMed - 2 year(s) ago
This systematic review has identified promising metabolites for further study in CF. Certain metabolites may provide clinical potential in predicting or diagnosing PEx, but further validation studies are required. With better tools to aid in the earlier identification of PEx, clinicians can implemen …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma - PubMed - 2 year(s) ago
The application of large-scale metabolomic profiling provides new opportunities for realizing the potential of omics-based precision medicine for asthma. By leveraging data from over 14,000 individuals in four distinct cohorts, this study identifies and independently replicates 17 steroid metabolite …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 2Combined Omic Analyzes of Cerebral Thrombi: A New Molecular Approach to Identify Cardioembolic Stroke Origin - 3 year(s) ago
Background and Purpose: The diagnosis of cardioembolic stroke can be challenging for patient management in secondary stroke prevention, particularly in the case of covert paroxysmal atrial fibrillati
Source: StrokeCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Metabolic alterations in a rat model of takotsubo syndrome - 3 year(s) ago
AbstractAims. Cardiac energetic impairment is a major finding in takotsubo patients. We investigate specific metabolic adaptations to direct future therapies.Me
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Are energy deficits the cause of a “broken” #heart? New study finds #Takotsubo syndrome is associated with #metabolomic dysregulation in glycolytic and beta-oxidation pathways https://t.co/kFig9q0xHq @CVR_TomaszGuzik @DrMikeDrozd #thinkPET #HeartFailure #CardiovascularResearch https://t.co/d43XR6ayAy
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Mashup Score: 1Metabolomic Profiling Reveals Sex Specific Associations with Chronic Obstructive Pulmonary Disease and Emphysema - PubMed - 3 year(s) ago
Susceptibility and progression of lung disease, as well as response to treatment, often differ by sex, yet the metabolic mechanisms driving these sex-specific differences are still poorly understood. Women with chronic obstructive pulmonary disease (COPD) have less emphysema and more small airway di …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
#Metabolomic study from Zhiyong Du et al. update molecular insights of clinical phenotypes and #cardiovascular risk in patients with homozygous familial #hypercholesterolemia #HoFH More and complexer metabolic abnormalities than previously known: https://t.co/tWJnx77o3Z https://t.co/QI2GthX6sG