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Mashup Score: 0Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association - 7 month(s) ago
AbstractBackground and Aims. Low birth weight is a common pregnancy complication, which has been associated with higher risk of cardiometabolic disease in later
Source: academic.oup.comCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0
Background: Education, intelligence, and cognition are associated with hypertension, but which one plays the most prominent role in the pathogenesis of hypertension and which modifiable risk factors
Source: HypertensionCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Independent of intelligence and cognition, #education is causally associated with #hypertension via mediating pathways of obesity, depression, and lipids, by #Mendelian randomization. @tiangewang1031 #education #hypertension #Mendelian randomization https://t.co/JKoYtqIHjo https://t.co/YM1gySDeOL
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Mashup Score: 10
Abstract In this second of a 5-part Focus Seminar series, we focus on precision medicine in the context of vascular disease. The most common vascular disease worldwide is atherosclerosis, which is …
Categories: Expert Picks, Latest HeadlinesTweet-
Understand how genetics play a role in #atherosclerosis vs #Mendelian vascular diseases like Marfan by brushing up with #JACC's focus seminar on #PrecisionMedicine ➡️ https://t.co/DhRh8FWfaK #NYCVS #CardioTwitter #CardioEd @kovacic_jason @GeneticHeartDoc https://t.co/6xTREJOzUb
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Mashup Score: 8Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization - 2 year(s) ago
Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provi
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#OriginalResearch: A causal relationship with #HeartFailure was identified for 8 circulating proteins, using #proteomics and #Mendelian randomization @DrRKarra @AH_AlbertHenry @tomlumbers #AHAJournals https://t.co/x0Hv851Vkf https://t.co/uEvXRuGURa
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Mashup Score: 0Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model - 2 year(s) ago
Author summary For causal inference, inverse-variance weighting (IVW) and Egger regression are two of the most widely applied Mendelian randomization methods nowadays. IVW is the most powerful under the perhaps too restrictive assumption that all IVs are valid, while Egger regression is often unnecessarily too flexible in assuming all IVs to be invalid with uncorrelated pleiotropic effects. In…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
🚨 A new model for #mendelian randomization: Lin et al present a combination model of inverse-variance weighting and Egger regression The model is higher powered, more robust to pleiotropy, & accounts for uncertainties in model/IV selection https://t.co/0S4QQ7HZ3p
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Mashup Score: 6Systematic review of Mendelian randomization studies on risk of cancer - BMC Medicine - 2 year(s) ago
Background We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence. Methods We searched PubMed and Scopus up to 06/10/2020 for MR studies investigating the association of any genetically predicted risk factor with cancer risk. We categorized the reported associations based on a priori…
Source: BioMed CentralCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A systematic review of #Mendelian randomization studies on risk of #cancer. Read it here: https://t.co/ngKZcEhSU3 https://t.co/8BVRaI9TAz
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Mashup Score: 0Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model - 2 year(s) ago
Author summary For causal inference, inverse-variance weighting (IVW) and Egger regression are two of the most widely applied Mendelian randomization methods nowadays. IVW is the most powerful under the perhaps too restrictive assumption that all IVs are valid, while Egger regression is often unnecessarily too flexible in assuming all IVs to be invalid with uncorrelated pleiotropic effects. In…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Lin et al present a combination model of inverse-variance weighting and Egger regression for #mendelian randomization The model is higher powered, more robust to pleiotropy, & accounts for uncertainties in model/IV selection https://t.co/0S4QQ7HZ3p
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Mashup Score: 0Diet‐Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People - 2 year(s) ago
Background Dietary intake and blood concentrations of vitamins E and C, lycopene, and carotenoids have been associated with a lower risk of incident (ischemic) stroke. However, causality cannot be …
Categories: Cardiology News and Journals, Latest HeadlinesTweet-
No causal effect of dietary #antioxidants on #stroke risk found when using #Mendelian randomization analysis #AHAJournals @drRNoordam https://t.co/2OU0GQCk6w
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Mashup Score: 5Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study - 2 year(s) ago
Background Obstructive sleep apnea (OSA) has shown to be associated with an increased risk of atrial fibrillation in observational studies. Whether this association reflect causal effect is still u…
Categories: Cardiology News and Journals, Latest HeadlinesTweet-
#Mendelian #randomization analysis suggests that sleep apnea has a causal effect on atrial fibrillation risk #AHAJournals https://t.co/we53FcN5le https://t.co/9uEOmD36Ya
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Mashup Score: 0Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data - 3 year(s) ago
Author summary Uncovering causal mechanisms between risk factors and disease is challenging with observational data because of unobserved confounding. Mendelian randomization offers a potential solution by replacing an individual’s observed risk factor data with an unconfounded genetic proxy measure. Over the last decade an array of methods for performing Mendelian randomization studies (MR)…
Source: journals.plos.orgCategories: Latest HeadlinesTweet-
Barry et al @jack_bowdenjack present a method for applying summary data #Mendelian randomization methods using individual level data from one cohort study The method intentionally creates collider bias, which can be estimated to correct results https://t.co/rvgIjM1X3N
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Low birth weight and early targeted cardiovascular disease prevention strategies: read the news on #EHJ! #mendelian #randomization #birth #weight #cardiovascular #risk #disease #EHJ #cardiotwitter @escardio @ESC_Journals https://t.co/ezXsAB5yBy https://t.co/RNAEeTJF0F