Approximately 100 years before the discovery of IgE, Charles Blackley1 described the use of scratch testing to identify pollens responsible for symptoms of hay fever, and in 1911, Robert Cooke introduced the use of intradermal testing.2 Today, modifications of the scratch and intradermal tests, the skin prick test and the skin puncture test, provide the most frequently used tests by allergists to identify allergen-specific IgE sensitivity. Lewis and Grant introduced the prick skin test in 1926, and Morrow Brown proposed the skin puncture test in 1981, both of which provided better sensitivity and reproducibility than the earlier scratch test.