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Mashup Score: 105
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 167
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 162
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 6 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/iBqDFBU2KY @WeizmannScience @TelAvivUni #Metastasis https://t.co/JY1wVUdAyD
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Mashup Score: 8Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary - 7 month(s) ago
Abstract. Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases. Spatial profiling revealed that metastasis-associated immune cells were present in the metastasis core, with the exception of TREM2+ regulatory macrophages uniquely enriched at the metastatic invasive margin, consistent across both murine models and human patient samples. These regulatory macrophages (Mreg) contribute to the formation of an immune-suppressive niche, cloaking tumor cells from immune surveillance. Our study provides a co
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Spatial & Temporal Mapping of #BreastCancer Lung Metastases Identify TREM2 #Macrophages as Regulators of the Metastatic Boundary, by @IdoYofe @ShamiTamar, Noam Cohen, Tomer Landsberger, @ErezNeta, @IdoAmitLab et al. https://t.co/YlACKewCgv @WeizmannScience @TelAvivUni #Metastasis https://t.co/ovY4dimzeG
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Mashup Score: 0
Chakraborty et al. demonstrate that a subset of tissue-resident alveolar macrophages shows greater capacity for efferocytosis and prevents hyperinflammation fol
Source: rupress.orgCategories: Infectious Disease, Latest HeadlinesTweet-
🏋️ How to train your immune cells! Scientists with Dr. @jalees_rehman at @UIC_BMG studied lung-resident alveolar #macrophages (AMs) with trained immunity and observed that trained AMs showed greater resilience to #pathogen-induced cell death. @JExpMed | https://t.co/khoosAgkrb https://t.co/wC3or6OFtL
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Mashup Score: 2TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis - 8 month(s) ago
TGF-β induces a distinct macrophage phenotype that promotes coagulation and worsens survival during sepsis.
Source: www.science.orgCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 0
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.
Source: www.futuremedicine.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages - 9 month(s) ago
Key Points. LPS increased phagocytosis, NADPH oxidase activity, hypoxic signals, and inflammation.NAM increased NAD and posttranslational modifications to inhib
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 4SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor - 10 month(s) ago
Key Points. SARS-CoV-2 ORF8 but not IL-17 upregulates cytokines in monocytes/macrophages.Monocytes and macrophages infected with SARS-CoV-2 do not express IL-17
Categories: Allergy-Immunology, Latest HeadlinesTweet
In a new @SciImmunology Review, scientists discuss how resident tissue #macrophages go beyond immunity to keep organs thriving. https://t.co/mApUmuomGx https://t.co/ohKQGnQhIv