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Mashup Score: 3Live cell microscopy of mitochondria-lysosome contact site formation and tethering dynamics: STAR Protocols - 2 year(s) ago
Summary Mitochondria-lysosome contact sites are critical for maintaining cellular homeostasis by regulating mitochondrial and lysosomal network dynamics and mediating metabolite exchange. Here, we present a protocol to quantitatively analyze the formation and tethering duration of mitochondria-lysosome contact sites by using time-lapse live confocal microscopy of LAMP1 and TOMM20. Although this…
Source: star-protocols.cell.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 7Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair - Nature Communications - 2 year(s) ago
Activation of ESCRT prevents potentially lethal outcomes of minor perturbations in lysosomal integrity. Here authors show that Ca2 + -activated scrambling of sphingomyelin and its cytosolic turnover drives lysosomal repair independently of ESCRT.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Ca2+-activated scrambling of sphingomyelin and its cytosolic turnover drives lysosomal repair independently of ESCRT @Patrick_Niekamp @HolthuisL #MembraneRepair #Sphingolipid #Scramblase #Lysosome #Infection https://t.co/1HnmM04cNP
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Mashup Score: 4
mTORC1, central regulator of cell growth and autophagy suppressor, is activated on the lysosome surface, but its local role in lysosomal biology remains unclear. Here the authors show STK11IP is a substrate of mTORC1 that regulates lysosomal acidification through V-ATPase and represses autophagy.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
The Yu lab identifies the mTORC1 substrate STK11IP as a V-ATPase regulator #lysosome https://t.co/Dth6ZMweDU
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Mashup Score: 2
(2022). SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death. Autophagy. Ahead of Print.
Source: Taylor & FrancisCategories: Infectious Disease, Latest HeadlinesTweet-
This week's review! 📚 A team at the Chinese University of Hong Kong (@CUHKofficial) explore the emerging evidence that #SARSCoV2 targets 🎯 the #lysosome to mediate airway inflammatory cell death. https://t.co/bCHGENYlMQ https://t.co/aIYzGH0gNx
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Mashup Score: 2Machinery, regulation and pathophysiological implications of autophagosome maturation - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Following their biogenesis, autophagosomes undergo maturation into degradative autolysosomes by fusing with late endosomes/lysosomes. This process — involving an array of molecular regulators of membrane dynamics — is essential for autophagic degradation, and its deregulation can lead to disease, including neurodegeneration, muscle diseases and cancer, and propagation of pathogens.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
Also in November issue: #Review by Yan Zhao, Patrice Codogno & Hong Zhang describing machinery of autophagosome maturation, regulation oft he process and its pathophysiological implications #autophagy #autophagosome #lysosome https://t.co/0c4NxsFd79 https://t.co/pS9RnZqaa4
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Mashup Score: 18
Rationale: Dominant heterozygous variants in filamin C (FLNC) cause diverse cardiomyopathies, although the underlying molecular mechanisms remain poorly understood. Objective: We aimed to define the
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Agarwal & colleagues found altered #protein turnover and increased #lysosome content in human #iPSC derived #cardiomyocytes with #FLNC variants that cause #cardiomyopathy. Learn more at https://t.co/UAr6YxCghR @radhikawal @christoepfer @subra_sun https://t.co/W4OAINZtXF
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Mashup Score: 14Machinery, regulation and pathophysiological implications of autophagosome maturation - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Following their biogenesis, autophagosomes undergo maturation into degradative autolysosomes by fusing with late endosomes/lysosomes. This process — involving an array of molecular regulators of membrane dynamics — is essential for autophagic degradation, and its deregulation can lead to disease, including neurodegeneration, muscle diseases and cancer, and propagation of pathogens.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
Read out new #Review by Yan Zhao, Patrice Codogno & Hong Zhang describing machinery of autophagosome maturation, regulation oft he process and its pathophysiological implications #autophagy #autophagosome #lysosome https://t.co/0c4NxsFd79 https://t.co/5xsmns29UN
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Online in @STARProtocols: Dr. Yvette Wong's lab @NMNeurology @NorthwesternMed @NUFeinbergMed describing live-cell imaging and quantitative analysis of #mitochondria-#lysosome contact site dynamics using time-lapse #confocal microscopy:https://t.co/QAnU3Ty5u3 https://t.co/9BmgqGsNva