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Mashup Score: 0Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau - Nature Communications - 2 year(s) ago
Here, the authors report that α-synuclein phase-separates into liquid condensates with positively charged polypeptides such as Tau. The condensates undergo different maturation processes, including the formation of α-synuclein/Tau amyloid hetero-aggregates inside the condensates.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid-liquid phase separation - Nature Communications - 2 year(s) ago
The authors introduce a unique single-droplet surface-enhanced Raman scattering (SERS) methodology that illuminates a wealth of molecular information within the mesoscopic liquid condensed phase of Fused in Sarcoma in the absence and presence of RNA.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from the @SamratLabMohali introduce a single-droplet surface-enhanced Raman scattering (SERS) methodology to access molecular information within the condensed phase of FUS in the absence and presence of RNA. #LLPS https://t.co/CTO3PQ1TyH https://t.co/w2NJZnd4Qa
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Mashup Score: 2
Autism impacts synapses. This study reports that autism-linked mutations of CTTNBP2 regulate phase separation to control synaptic enrichment of that protein. A zinc-induced liquid-to-gel transition improves synaptic retention of CTTNBP2 and SHANK3.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Autism-linked mutations of CTTNBP2 regulate #LLPS to control synaptic protein enrichment. A #Zinc-induced liquid-to-gel transition improves synaptic retention of CTTNBP2 and SHANK3. @YPH_yiping, @kuohsia, @IMBSinica, @shih_puyun, @iipqwo120 #ASD #Synapse https://t.co/B5yIgVOdYk https://t.co/ojeQssWPjE
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Mashup Score: 11Liquid–liquid phase separation drives cellular function and dysfunction in cancer - Nature Reviews Cancer - 2 year(s) ago
Liquid–liquid phase separation (LLPS) has been revealed as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells. This Perspective discusses how LLPS shapes the biochemical landscape of cancer cells, providing insight into emerging findings of dysregulated LLPS promoting cancer pathology.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In the April issue of @NatureRevCancer | Perspective from @doctorsohum & @jinzhanglab discussing how liquid-liquid phase separation (#LLPS) drives cellular function and dysfunction in cancer. https://t.co/m42lGnDDq3 @natrescancer @UofCalifornia https://t.co/tePjS2EoWV
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Mashup Score: 8Liquid–liquid phase separation drives cellular function and dysfunction in cancer - Nature Reviews Cancer - 2 year(s) ago
Liquid–liquid phase separation (LLPS) has been revealed as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells. This Perspective discusses how LLPS shapes the biochemical landscape of cancer cells, providing insight into emerging findings of dysregulated LLPS promoting cancer pathology.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NEW Perspective! @doctorsohum & @jinzhanglab discuss how liquid-liquid phase separation (#LLPS) shapes the biochemical landscape of #cancer cells, providing insight into findings of dysregulated LLPS promoting cancer pathology. https://t.co/m42lGnDDq3 @natrescancer @UofCalifornia https://t.co/auUepHDxZy
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Mashup Score: 1Voices of the new generation: establishing yourself as a PI in a competitive field - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Jonathon Ditlev shares his thoughts on building a research programme in a competitive field.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In our November issue check out this World View, where Jonathon Ditlev shares his thoughts on building a research programme in a competitive field of #LLPS #PhaseSeparation #BiomolecularCondensates @Jonathon_Ditlev https://t.co/Y5x05OoJym FREE pdf: https://t.co/dNs0gIRq8J https://t.co/a2laP4nAxT
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Mashup Score: 0Phase separation in biology - 3 year(s) ago
A collection of Reviews from Nature Reviews Molecular Cell Biology, and research papers from the Nature journals, on phase separation mechanisms and the roles of biomolecular condensates.
Source: www.nature.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Check out also our Collection focusing on Phase separation in biology #LLPS #BiomolecularCondensates https://t.co/ETwL4yu2cm https://t.co/w05N5eg60G https://t.co/V5dexSKApI
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Mashup Score: 7Voices of the new generation: establishing yourself as a PI in a competitive field - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Jonathon Ditlev shares his thoughts on building a research programme in a competitive field.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In this World View article Jonathon Ditlev shares his thoughts on building a research programme in a competitive field of #LLPS #PhaseSeparation #BiomolecularCondensates @Jonathon_Ditlev @SickKidsNews https://t.co/Y5x05OoJym https://t.co/n6oIZOW8Pg
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Mashup Score: 1A framework for understanding the functions of biomolecular condensates across scales - 4 year(s) ago
Biomolecular condensates are membraneless molecular assemblies formed via liquid–liquid phase separation. They have a plethora of roles, ranging from controlling biochemical reactions to regulating cell organization and cell function. This article provides a framework for the study of condensate functions across these cellular length scales, offering to bring new understanding of biological…
Categories: Allergy-Immunology, Latest HeadlinesTweet-
A must read Roadmap by Mike Rosen and co: A framework for understanding the functions of biomolecular condensates across scales @a_s_lyon @UTSWNews #PhaseSeparation #LLPS #BiomolecularCondensates https://t.co/tFxhDPvfiB !FREE! pdf: https://t.co/QMefoHhi3Z https://t.co/THymOjOY15
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Here, α-synuclein and Tau are reported to co-phase separate and to form amyloid hetero-aggregates inside the condensates upon droplets aging. @Nunilo_cc, @BIFI_Instituto, @unizar, #LLPS, #IDPs, #amyloids, #SingleAndMingle https://t.co/eW1ayA5iQq https://t.co/qtBmkBQCfC